YEMITAN OMONIYI KAYODE

Pharmacology, Therapeutics & Toxicology

At the Pharmacology, Therapeutics & Toxicology department office

Appointment on Visitation important

Topic: Pharmacological Evaluations And Toxicological Assessments Of Medicinal Plants Extracts With CNS Activities In Humans

Description: Parts of medicinal plants are currently gaining popularity worldwide in various chronic ailments of the central nervous system, among others. Various central nervous system effects, as well as toxicological end-points are being investigated; first in rodents, with a view to ascertaining and predicting their efficacy and safety claims in humans. The final part of the research interest would incorporate all the results from our studies as well as studies by other workers on the plants extracts, integrate them for mathematical modeling with a view to achieving the Risk Assessment profiling of these medicinal plants, employing the systematic toxicological approach used in Risk Assessment i.e. Hazard Identification, Dose-Response analysis, Exposure Quantification and Risk Characterization . The findings from these assessments will significantly contribute to knowledge and use of these these plant extracts, especially as it concerns their medicinal values.

#	Certificate	School	Year
1.	Ph.D (Pharmacology)	Department of Pharmacology, College of Medicine of the University of Lagos	2008

Mechanistic Assessment of Pro-Fertility Action of Hydro-Ethanol Root Extract of Lecaniodiscus cupanioides on Cisplatin-induced Male Reproductive Toxicity in Rats

Introduction:We studied the pro-fertility, phytochemicals and mechanisms of action of the hydro-ethanol root extract of Lecaniodiscus cupanioides, HELC, which is claimed to be effective for the treatment of erectile dysfunction and male infertility.Methods:The fertility effect of pre- and post-treatment of two extract doses, 100 400 mg/kg, p.o. of 1:1 HELC was investigated against cisplatin 7 mg/kg, i.p. -induced spermatotoxicityfollowing 21 days treatment in rats. The weights of the body, testes, seminal vesicles and caudae epididymis, sperm quality and counts, the concentrations of testosterone, FSH and LH, and activities of the testicular antioxidants- GSH-Px, GSH, CAT and SOD and TBARS were assessed. The phytochemicals present in HELC were also investigated.Results:At P & 0.05, compared to the cisplatin-treated groups, the body and reproductive organs weights were significantly increased in the pre- and post-HELC treatment groups; sperm counts and motility were significantly increased, but percentage abnormal sperms in the pre- and post- HELC groups were significantly reduced; significant reduction in serum LH and FSH levels were recorded, but testosterone was increased in the HELC groups; also there were significant decreases in testicular activities of GSH-Px, GSH, CAT and SOD and TBARS in the pre- and post-treatment HELC groups. Phytochemicals present in HELC were detected to be phenols, tannins, saponins and anthraquinones.Contribution to knowledge:HELC produces preventive and curativepro-fertility and antioxidant effects in the reproductive organs of male rats, suggesting androgenic, spermatogenic and testicular antioxidant effects probably due to presence of phenols and tannins phytochemicals.

YEMITAN OMONIYI is a Professor at the Department of Pharmacology, Therapeutics & Toxicology

YEMITAN has a Ph.D in Pharmacology from Department of Pharmacology, College of Medicine of the University of Lagos