Neuropathology/ Head &neck Pathology And Forensic Pathology
Pathology and Forensic Medicine
At the Pathology And Forensic Medicine department office
Appointment on Visitation important
Topic: Mutational Analysis Of Endoscopic Biopsies: Risk Assessment And Therapeutic Tool For Prevention And Management Of Colorectal Carcinoma In Lagos, Nigeria.
Colorectal carcinoma (CRC) is a leading cause of cancer mortality worldwide. However evidence from hospital-based studies in Nigeria point to an incidence rate which has slowly been increasing over several decades due to rapid urbanisation and adoption of Western dietary patterns.
1.To determine the frequency of microsatellite instability (DNA mismatch repair gene mutations) from patients screened at the Lagos State University Teaching Hospital.
2. To categorise the microsatellite unstable colorectal tumours into sporadic and familial (Lynch syndrome) groups to assess the risk level of Nigerian patients and highlight the relevance of these mutations in prevention of CRC.
3.To determine the proportion of colorectal carcinoma patients who will potentially benefit from targeted therapy options.
Method: All endoscopic biopsies submitted for histologic diagnosis over an 18-month period will be used for this study. A sample size of 110 is needed. This arose from the use of Cochrane formula.
The data to be accessed from all cases, where possible, will include age, sex, clinical presentation, family history of CRC, social history (smoking, alcohol intake), previous history of treatment of CRC, previous G.I. surgery, history of metastases, biopsy site, histologic type, tumour grade, depth of tumour penetration, lymphatic or vascular invasion and perineural invasion.This research will be carried out at LASUTH by the Departments of Pathology and Forensic Medicine, Internal Medicine and Surgery. All samples which meet the selection criteria will then be subjected to automated immunohistochemical analysis for MSI, KRAS, BRAF expression with the aid of Tissue Microarray (TMA) technique.
The genetic analysis will become a useful tool to strengthen routine clinical screening in the assessment of risk and prevention of colorectal carcinoma.
It will also advance the knowledge
and practice of personalised medicine in the management of cancers in the
|1.||FMCPath (HISTOPATHOLOGY)||Faculty of Pathology of the National Postgraduate Medical College of Nigeria.||2010|
SOYEMI SUNDAY is a Professor at the Department of Pathology and Forensic Medicine
SOYEMI has a FMCPath in HISTOPATHOLOGY from Faculty of Pathology of the National Postgraduate Medical College of Nigeria.