SORUNKE EKUA MODUPEORE

Preventive Dentistry

At the Preventive Dentistry department office

Appointment on Visitation important

Topic: Awareness Of Nigerian Population About Periodontal Disease And Its Relationship With Systemic Disease

Description: To assess the level of awareness of healthcare workers regarding gingival bleeding as an early sign of periodontal disease.

#	Certificate	School	Year
1.	BACHELOR OF DENTAL SURGERY BDS ()	COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN	1983

EVALUATION OF SALIVARY PRO-INFLAMMATORY CYTOKINE PROFILES (IL-1β, IL-6, AND TNF-α) ACROSS DIFFERENT SEVERITIES OF PERIODONTAL DISEASES IN A NIGERIAN POPULATION: A CROSS-SECTIONAL STUDY

Introduction: Periodontal diseases are biofilm induced inflammatory conditions characterized by progressive destruction of the supporting tissues of the teeth. Contemporary understanding recognizes that periodontal tissue breakdown is driven primarily by a dysregulated host immune inflammatory response rather than direct bacterial damage alone. Pro inflammatory cytokines, particularly interleukin 1β (IL 1β), interleukin 6 (IL 6), and tumor necrosis factor α (TNF α), play central roles in connective tissue degradation and alveolar bone resorption. Conventional clinical diagnostic parameters such as probing pocket depth and clinical attachment loss reflect historical tissue damage and have limited ability to detect active disease. Saliva offers a non invasive and biologically relevant medium for assessing periodontal inflammation. However, data evaluating salivary cytokine profiles across the periodontal disease severity spectrum, particularly in Nigerian populations, remain limited.

Aim: To evaluate salivary pro inflammatory cytokine profiles as diagnostic biomarkers by comparing their concentrations across periodontal disease severities and correlating these profiles with clinical periodontal parameters in a Nigerian population.

Methods: This hospital based cross sectional analytical study will recruit adult patients aged 18–70 years attending the dental Clinic at Lagos State University Teaching Hospital. Participants will be classified as periodontally healthy, having gingivitis, or having periodontitis stages I–IV using the 2017 AAP/EFP classification following clinical and radiographic examination. Unstimulated whole saliva will be collected by passive drool for analysis of IL 1β, IL 6, and TNF α concentrations using immunoassay techniques. Associations between salivary cytokine levels and clinical periodontal parameters will be assessed using correlation and regression analyses. Receiver operating characteristic curves will evaluate the diagnostic performance of the cytokines.

Expected Outcome: The study aims to clarify the relationship between salivary cytokine profiles and periodontal disease severity and provide locally relevant evidence supporting the use of salivary biomarkers as adjuncts to conventional periodontal diagnosis in Nigeria

SORUNKE MODUPEORE is a Associate Professor / Reader at the Department of Preventive Dentistry

SORUNKE has a BACHELOR OF DENTAL SURGERY BDS in from COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN