Reproductive Physiology And Developmental Programming
At the Physiology department office
Appointment on Visitation important
Topic: Reproductive Physiology And Developmental Programming
Implications of natural/synthetic products, hypertension, variable stress, and metabolic syndromes on reproductive physiological functions. Of particular interest are synthetic/natural products with the potential of modifying reproductive indices, fertility, sexual functions, and trans-generational reproductive functions. Some of these agents include Caffeine and medicinal plants like Tridax procumbens, Ricinus communis, Corpolobia lutea, Azadirachta indica, Kigelia africana, and Sphenocentrum jollyanum. My investigations involve the use of majorly in-vivo and in-vitro experimental models.
The impetus for this is the wide and continuous use of these agents in African cultures (Nigeria inclusive). Studies have also shown that there is wider consumption of complementary and alternative medicine in the population in the country.
How (mechanisms) these agents modify reproductive functions, sexual functions, and generational developmental programming of reproductive functions from these exposures were investigated with compelling outcomes (validated scientific evidence)
|1.||Ph.D (Physiology/Reproductive Physiology and Developmental Programming)||Department of Physiology, University of Ibadan||2012|
Ongoing research on natural agents and gestational variable stress
1. Elucidating mechanisms of actions of a few of these medicinal plants like Tridax procumbens, Corpolobia lutea, Kigelia Africana, Sphenocentrum jollyanum on reproductive physiology using in-vivo and in-vitro experimental models.
2. Investigating the role of antioxidant supplementation during timed (early/late/reproductive organ organogenesis period) gestational variable stress exposure on maternal and fetal reproductive and sexual functions. I am also currently investigating the probable mechanism(s) involved in the attenuation by antioxidant supplementation. One major limitation in the earlier study was our inability to determine protein expression of channels critical for uterine contraction and key stress genes in the uterine tissue.
3. Exploring the prospect of developing a few of these natural agents with promising nutritional and healthy benefits/safety into drug/beverages/foods for animals and humans use. (Translational implication of Research). Some of these natural agents like Tridax procumbens (leaves), Kigelia Africana (stem and fruits), Corpolobia lutea roots, have shown prospects at reversing erectile dysfunction, hypertension, diabetes, and associated reproductive impairments.
SALAMI SHAKIRU is a Senior Lecturer at the Department of Physiology
SALAMI has a Ph.D in Physiology/Reproductive Physiology and Developmental Programming from Department of Physiology, University of Ibadan