SALAMI SHAKIRU ADEMOLA

Physiology

At the Physiology department office

Appointment on Visitation important

Topic: Reproductive Physiology And Developmental Programming

Description: Implications of natural/synthetic products, hypertension, variable stress, and metabolic syndromes on reproductive physiological functions. Of particular interest are synthetic/natural products with the potential of modifying reproductive indices, fertility, sexual functions, and trans-generational reproductive functions. Some of these agents include Caffeine and medicinal plants like Tridax procumbens, Ricinus communis, Corpolobia lutea, Azadirachta indica, Kigelia africana, and Sphenocentrum jollyanum. My investigations involve the use of majorly in-vivo and in-vitro experimental models. The impetus for this is the wide and continuous use of these agents in African cultures Nigeria inclusive . Studies have also shown that there is wider consumption of complementary and alternative medicine in the population in the country. The mechanisms of how these agents modify reproductive functions, sexual functions, and generational developmental programming of reproductive functions from these exposures were investigated with compelling outcomes and validated scientific evidence

#	Certificate	School	Year
1.	Ph.D (Physiology/Reproductive Physiology and Developmental Programming)	Department of Physiology, University of Ibadan	2012

Natural and synthetic agents on reproductive functions

Follow-up studies on the promising ameliorative impact of Tridax procumbens on erectile dysfunctions from earlier studies were also conducted. The effect of Tridax procumbens on the erectile dysfunctions caused by multiple variable stressors, and experimentally induced diabetes were investigated

Findings: 

a. Chronic variable stress-impaired contractile mechanisms mediated by nitric oxide, calcium channels, ATP-sensitive K+ channels, parasympathetic activation, and cyclic guanylyl cyclase activity. Supplementation with ethanol extract of Tridax procumbens leaf, however, ameliorated these impaired mechanisms through its potent antioxidant and hormonal activity.

b. Tridax procumbens treatment in streptozotocin-induced diabetic rats enhanced cavernosa activity by improving NO, guanylyl cyclase, and ATP-sensitive potassium channels while inhibiting receptor-operated calcium channels. TPL's anti-inflammatory, antioxidant, and androgenic properties contribute to the modulation of cavernosa activity in diabetes.

3. Other follow-up research was also conducted using caffeine (concluded),

4. Prepubertal caffeine intake had an erectogenic effect on the cavernous tissues in the presence of glibenclamide, nifedipine, and L-NAME. Inhibitors of prostacyclin (indomethacin) and guanylyl cyclase (methylene blue) militate caffeine-induced relaxation. These effects were reversed after recovery.

Others are Sargassum plant, Zinziber officiniale, Kigelia africana, and Terminalia glaucescens (ongoing) using invivo and invitro experimental models

SALAMI SHAKIRU is a Associate Professor / Reader at the Department of Physiology

SALAMI has a Ph.D in Physiology/Reproductive Physiology and Developmental Programming from Department of Physiology, University of Ibadan