At the Physiology department office
Appointment on Visitation important
Topic: Physiological Mechanisms Of Medicinal Plants Used In The Management Of Cardiovascular Diseases.
Description: Traditional medicine has potential that have not been fully exploited andwhich can complement and help in advancing modern medicine. Plants are rich in a wide variety of secondary metabolites such as tannins, terpenoids, alkaloids and flavanoids. Many of which have been found to exhibit in vitro vasorelaxant activities of smooth muscle. My area of interest focuses on improve understanding of the molecular mechanism and efficacy by which medicinal plants alters the physiology of endothelial and vascular smooth muscle cells in health and hypercontractility diseases. The information will help to bridge the gap between modern medicine and traditional medicine making it possible to compliment the modern medicine and also contribute to its advancement
|1.||Ph.D (Physiology)||Department of Physiology, University of Ibadan College of Medicine, Ibadan||2008|
Involvement of Na - Ca2 exchange in the endothelium- independent vasorelaxation -induced by Tridax procumbens leave extract in isolated rat aortic smooth muscle.
Objective: In this study we investigate the involvement of Na - K -pump and Na - Ca2 exchanger in the vasorelaxant activities of Tridax procumbens leave extract (TPLE) in isolated rat superior mesenteric arteries. Methods: Superior mesenteric artery isolated from healthy, young adult Wistar rats (250-300 g) and pre-contracted with phenylephrine (PE) (10-7M) were treated with various concentrations of aqueous extract of TPLE (0.3-1.8 mg/ml). The changes in arterial tension was recorded and interaction between TPLE with selective blocker of Na - K ATPase (Ouabain) and putative Na -Ca2 exchanger inhibitor (NiCl2) were evaluated. Results: The result indicated that TPLE significantly inhibit the cumulative concentration response curves to phenylephrine (PE) (10-8-10-5M) in a concentration-dependent manner. Pre-treatment with both ouabain and nickel chloride (NiCl2), abolished the vasorelaxant responses of TPE. Also, TPLE reduced the relaxant effect with decreased extracellular Na concentration. TPE-induced vasorelaxation was completely abolished in a Na -free solution, a condition that eliminates the influence of the forward mode of the exchanger. Conclusion: The results provide direct hypothetical evidence that the activation of Na - K ATPase and stimulation of the forward mode of the Na -Ca2 exchanger contribute to the vasorelaxation induced by TPLE in mesenteric artery.
SALAHDEEN Hussein is a Professor at the Department of Physiology
SALAHDEEN has a Ph.D in Physiology from Department of Physiology, University of Ibadan College of Medicine, Ibadan