Obstetrics And Gynaecology
Obstetrics and Gynaecology
At the Obstetrics And Gynaecology department office
Appointment on Visitation important
Topic: RESEARCH INTEREST
Description: My current research orientation is focussed on two major areas in obstetrics and gynaecology: maternal medicine and gynaecological oncology.Maternal mortality in Nigeria is one of the highest in the world and recent research has revealed that medical conditions especially hypertensive disorders of pregnancy is now the leading cause. Research in various areas of maternal medicine will help identify key areas where appropriate interventions need to be put in place.The story of gynaecological oncology in Nigeria has been a pathetic one, characterised by late and advanced stage presentation and lack of economic power to afford investigations and treatment. My resent research in this area is focused on the preventive aspects of gynaecological oncology and elucidating the factors associated with late presentation so that appropriate recommendations can be made.
|1.||MD (Doctor of Medicine) (Obstetrics and Gynaecology)||National Postgraduate Medical College of Nigeria||2020|
Comparison of HPV DNA testing to cytology for secondary screening in women with abnormalities on aided visual inspection
1Introduction: Organized cytology based cervical cancer screening has a major impact on morbidity and mortality from cervical cancer in the developed countries. Cytology based screening cannot be provided on a large scale in developing countries. We compared the performance of HPV DNA versus liquid based cytology (LBC) testing in diagnosing premalignant lesion of cervix in women with abnormalities on aided visual inspection of the cervix with lugol iodine (VILI) against gold standard histopathology.
Methods: Out of 2031 participants, 250 respondents were VILI positive and were studied further using HPVDNA testing/LBC and then colposcopy directed biopsies. Data obtained was analyzed using SPSS version 22 to generate descriptive statistics. Chi-square with Yates correction or fisher test was categorical variables. Diagnostic statistics viz. Sensitivity, Specificity, PPV, NPV, PL, NL were computed for the screening tests. Inter-rater agreement was calculated using the Cohen’s kappa
Results: Measure of inter-rater agreement using Kappa showed strong statistically significant correlation between HPVDNA and LBC (K =0.819, P = 0.001)
Fifty-three respondents (22.4%) had HPV infection and the most prevalent HPV serotypes were HPVs 35, 56, 16, 33 in a proportion of 16%, 12%, 11%, 9% respectively and 18.1% respondents had high risks HPV infection.
HPVDNA had slightly higher but not statistically significant sensitivity (97.62 vs 92.86), specificity (93.85 vs 92.30), PPV(77.36% vs 72.22%), NPV (99.45 vs 98.36%) and Accuracy (80.79% vs 78.13%) than LBC (all with P value greater than 0.05)
HPVDNA and /or LBC Co-testing in VILI positive led to a reduction in the performance of the test as compared with HPV or LBC as a stand-alone test.
Conclusion: VILI with synchronous HPVDNA testing might be a more applicable and effective alternative to multi-stage cytology-based screening test in cervical cancer prevention strategy.
RABIU KABIRU is a Professor at the Department of Obstetrics and Gynaecology
RABIU has a MD (Doctor of Medicine) in Obstetrics and Gynaecology from National Postgraduate Medical College of Nigeria