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Topic: MICELLAR CHARACTERIZATION, EQUILIBRIUM BINDING CONSTANT, AND THERMODYNAMICS STUDIES OF SOME AMPHIPHILIC AND HYDROPHOBIC DRUGS
The solubilization of organic compound in surfactant micelles is quite important in industrial applications being valuable in pharmaceutical formulations as a tool to improve the solubility of amphiphilic and hydrophobic drugs, and to protect them from degradation has been a subject of concern. Inorganic salts are present as different sodium salts in variable quantities in the intra and extra cellular biological fluid, hence the therapeutic effect of some drugs is often optimized by derivatization through conversion into a salt form using inorganic salts Aim: To determine how cationic surfactants can influence biological events. Study of the interaction of a broad spectrum antibiotics (tetracycline hydrochloride) and amitriptyline hydrochloride with hexadecyltrimethylammonium chloride in aqueous and solution of salts (KCl) over a temperature range of 298.1 K to 313.1 K. Methodology: Conductance measurement. (i) Characterization of the simplified model of bio membranes ( drug-micelles system) through (a) the determination the critical micelle concentration (b) determination of the aggregation number (c) evaluation of interaction parameters, (d) evaluation of drug-micelle composition and (e) the thermodynamics stability of the drug-mediated micelles. The micelle-encapsulated drug is expected have improved solubility, thereby making it bioavailable at low dosage
|1.||Ph.D (Physical Chemistry)||Adekunle Ajasin University, Akungba-Akoko, Ondo State||2016|
Micellization and Interaction of Cationic Surfactants with different hydrophobic group in polar organic solvent.
INTRODUCTION Surfactants are amphiphilic compounds with remarkable ability to influence the properties of the surfaces and interfaces. They are widely used in various industrial fields such as detergents, textile, and herbicides formulations. In many of these applications, the use of surfactant mixtures in some organic solvents improves significantly the performance over the single monomeric surfactant system. AIM The study aims at establishing the extent of ideality or otherwise in the mixed micelles of tetradecyltrimetyltrimethylammonium bromide (TTABr) and cetyltrimethylammonium bromide (CTABr) in water (AQ) and water-monoethanolamine (AQ-MEA) media at different mole fractions (1.0 to 0.6) and temperatures (298.1 to313.1 K).:METHOD conductance measurements .RESULTS so far: The critical micelle concentration values (CMC12) obtained in water was slightly lower than that obtained assuming an ideal mixing system. Substantial deviation from ideality was observed in the presence of AQ-MEA at all temperatures, suggestive of more favourable association in the mixed micelle at elevated temperatures. The values of the CMC12 was analyzed in the context of Rubingh’s model. The values of the composition of the mixed micelles (?1) showed that CTABr was dominant and the values of the interactions paramers (?12) were negative in AQ and AQ- MEA media with the values being more favourable in the latter case The values of the activity coefficients (f1,f2) were below unity. Enhancement of hydrophobic interactions occurred in AQ-MEA especially at 1.0: 0.9 mole fractional ratio.
WORK Yet To Be Done: The energetics of micellization is on going to ascertaing the feasible of the reaction.
OSUNDIYA MEDINAT is a Lecturer I at the Department of Chemistry
OSUNDIYA has a Ph.D in Physical Chemistry from Adekunle Ajasin University, Akungba-Akoko, Ondo State