Feto-maternal Medicine And Reproductive Health
Associate Professor / Reader
Obstetrics and Gynaecology
At the Obstetrics And Gynaecology department office
Appointment on Visitation important
Topic: HAEMATOLOGICAL INDICES IN PREGNANCY AND PUERPERIUM
Background: Pregnancy is a time of considerable maternal adaptation during which the range of normal laboratory values for commonly requested clinical investigations is wider and even more arbitrary than in the non-pregnant state. There is a dearth of information on the reference values for haematological indices particularly in relation to the trimesters of pregnancy and in the puerperium.
Objectives: To determine the reference values for various haematological indices in trimesters of pregnancy and puerperium in healthy pregnant and puerperal subjects compared to non-pregnant women. Methods: A cross-sectional prospective study involving 422 subjects carried out over a six-month period. Healthy pregnant, puerperal and non-pregnant subjects recruited and grouped into six. Each subjects had her socio-demographic data and anthropometry documented and haematological indices determined by automated analysis using the Coulter counter method.
The results were subjected to statistical analysis using 95% confidence intervals. Results: The difference in the mean haematocrit values in pregnancy was statistically significant between the first and second trimesters (P=0.026) and between the second and third trimesters (P=0.007). The mean RBC count also showed a significant difference between the first and second trimesters (P=0.032). Other red cell indices (MCV, MCH and MCHC) showed no statistically significant difference in between trimesters. The difference in the mean WBC count values was equally significant between the first and second trimester (P=0.023). A similar significant difference was observed in the mean platelet count between the first and third trimesters (P=0.002).
Conclusion: The lowest red cell parameters were recorded in the second trimester and there were varying statistically significant differences in the mean haematocrit, haemoglobin concentration, RBC, WBC and platelet values during the trimesters of pregnancy and the puerperium.
Contribution to knowledge: This study provides comprehensive reference values for interpreting haematological test among blacks.
|1.||FMCOG (Obstetrics and Gynaecology)||National Postgraduate Medical College of Nigeria||2011|
EVALUATION OF THE RISK FACTORS FOR PRETERM AND TERM DELIVERIES IN LAGOS
Preterm delivery is the second most leading cause of under-five deaths in the world and has been associated with poor neonatal outcomes especially in developing countries where management of severe and extreme preterm new-born is a challenge.
Objective: To compare the risk factors associated with preterm and term deliveries.
Method: A retrospective comparative study of one hundred and fifty patients with preterm delivery between 28-36 weeks’ gestation and one hundred and fifty control subjects with term delivery. Information was obtained on socio-demographic, obstetric and medical risk factors in both groups. Data obtained was analyzed using SPSS version 19.
Results: The significant risk factors for preterm delivery were multiple ( twin) pregnancy (P = 0.000), preterm premature rupture of membranes (P = 0.000), bleeding in pregnancy (P = 0.0), pathologic vaginal discharge in pregnancy ( P = 0.000), previous preterm delivery (P =0.01), significant fever in pregnancy [P = 0.05), malaria (P = 0.01), and hypertensive disorders in pregnancy [ Pre-eclampsia P = 0.000), Eclampsia (P = 0.01) ].
Conclusion: In concordance with previous studies, multiple gestation, previous preterm birth, hypertensive disorder, febrile illness, bleeding and pathologic vaginal discharge in pregnancy were identified risk factors for preterm delivery.
Findings will help identify antenatal patients with risk factors which will be modified to prevent adverse perinatal outcome.
OSHODI YUSUF is a Associate Professor / Reader at the Department of Obstetrics and Gynaecology
OSHODI has a FMCOG in Obstetrics and Gynaecology from National Postgraduate Medical College of Nigeria