OLOFINNADE ANTHONY TOPE

Pharmacology, Therapeutics & Toxicology

At the Pharmacology, Therapeutics & Toxicology department office

Appointment on Visitation important

Topic: Neurobiological Changes In Autism Spectrum Disorders: A Review Of Current Literature

Description: Background: Autism spectrum disorder ASD is an array of neurodevelopmental disorders that are characterised by the presence of cognitive and neurobehavioural deficits. Although the aetiology of ASD remains a mystery, its aetiopathogenesis has been attributed to genetic and non-genetic factors More recently, advances in clinical and preclinical research are also providing evidence of neurobiological and neuroanatomical changes in ASD Objectives: In this narrative review we discuss recent advances in our understanding of the neuroanatomical, neurobiological and neuropathological processes associated with ASD; with a view to relating clinical symptomatology with anatomical changes. Also examined is the impact of these advances on treatment options and health outcomes Strategy:This review examined extant literature to provide a comprehensive update on the relationship between neurobiological factors and ASD.

#	Certificate	School	Year
1.	Ph.D (Pharmacology)	Ladoke Akintola Universaity of Technology	2022

Prepubertal continuous dietary folate fortification enhances brain function of adult mice by modulating antioxidant status, inflammation and brain neurotransmitter levels

Abstract:Background: There is a growing body of knowledge in support of the beneficial effects of folic acid supplementation. However, while ampleevidence exists concerning beneficial effects on growth and haematologic parameters, possible effects of continuous folic acidsupplementation on the brain are less examined.ObjectivesTo investigate possible effect of dietary folic acid supplementation beginning in the prepubertal period on neurobehaviour, oxidativestress, inflammatory parameters and neurotransmitter levels in adult mice.MethodsForty-eight prepubertal male mice postnatal day 21 were randomly assigned into four groups of 12 n = 12 animals each. Mice weregrouped into normal control fed standard diet and three groups fed folic acid supplemented diet at 2.5, 5 and 10 mg/kg of feed.Daily food intake and weekly body weight were assessed. Animals were fed standard diet, or folic acid supplemented diet for a periodof eight weeks. On postnatal day 78, animals were exposed to behavioural paradigms Open-field, Y maze, radial arm maze, elevatedplus maze, bar test and models of behavioural despair . Twenty-four hours after the last behavioural test, animals were fastedovernight following which they were sacrificed, and blood taken for assessment of blood glucose, leptin, and insulin levels. The brainof the animals were also homogenised for the assessment of biochemical parameters lipid peroxidation, total antioxidant capacity,inflammatory markers, dopamine, brain derived neurotropic factor, acetylcholine and acetylcholinesterase activity .ResultsResults showed a concentration dependent increase/improvement in body weight, antioxidant status, memory scores in the radialarm and Y- maze and acetylcholine levels; and a decrease in food intake, blood glucose, insulin, and leptin level. A reduction in openfield behaviours, anxiety-related behaviours, and proinflammatory markers were also observed.ConclusionThe beneficial effects of prepubertal continuous dietary folate fortification in specific contexts relating to behaviour, cognition,oxidative status, metabolic hormones and brain neurochemistry as the animal ages are shown in the study.

OLOFINNADE ANTHONY is a Lecturer I at the Department of Pharmacology, Therapeutics & Toxicology

OLOFINNADE has a Ph.D in Pharmacology from Ladoke Akintola Universaity of Technology