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Topic: PrePubertal Continuous Dietary Folate Fortification Enhances Brain Function Of Adult Mice By Modulating Antioxidant Status, Inflammation And Brain Neurotransmitter Levels
Description: Background:There is a growing body of knowledge in support of the beneficial effects of folic acid supplementation. However, while ample evidence exists concerning beneficial effects on growth and haematologic parameters, possible effects of continuous folic acid supplementation on the brain are less examined. Objectives To investigate possible effect of dietary folic acid supplementation beginning in the prepubertal period on neurobehaviour, oxidative stress, inflammatory parameters and neurotransmitter levels in adult mice. Methods Forty-eight prepubertal male mice postnatal day 21 were randomly assigned into four groups of 12 n = 12 animals each. Mice were grouped into normal control fed standard diet and three groups fed folic acid supplemented diet at 2.5, 5 and 10 mg/kg of feed. Daily food intake and weekly body weight were assessed. Animals were fed standard diet, or folic acid supplemented diet for a period of eight weeks. On postnatal day 78, animals were exposed to behavioural paradigms Open-field, Y maze, radial arm maze, elevated plus maze, bar test and models of behavioural despair . Twenty-four hours after the last behavioural test, animals were fasted overnight following which they were sacrificed, and blood taken for assessment of blood glucose, leptin, and insulin levels. The brain of the animals were also homogenised for the assessment of biochemical parameters lipid peroxidation, total antioxidant capacity, inflammatory markers, dopamine, brain derived neurotropic factor, acetylcholine and acetylcholinesterase activity . Results Results showed a concentration dependent increase/improvement in body weight, antioxidant status, memory scores in the radial arm and Y- maze and acetylcholine levels; and a decrease in food intake, blood glucose, insulin, and leptin level. A reduction in open field behaviours, anxiety-related behaviours, and proinflammatory markers were also observed. Conclusion The beneficial effects of prepubertal continuous dietary folate fortification in specific contexts relating to behaviour, cognition, oxidative status, metabolic hormones and brain neurochemistry as the animal ages are shown in the study.
|Ladoke Akintola Universaity of Technology
Neuroinflammation and oxidative stress in Alzheimer s disease; Can nutraceuticals and functional foods come to the rescue?
Alzheimers disease AD , the most prevalent form of age-related dementia, is typified by progressive memory loss and spatial awareness with personality changes. The increasing socioeconomic burden associated with AD has made it a focus of extensive research. Ample scientific evidence supports the role of neuroinflammation and oxidative stress in AD pathophysiology, and there is increasing research into the possible role of anti-inflammatory and antioxidative agents as disease modifying therapies. While, the result of numerous preclinical studies has demonstrated the benefits of anti-inflammatory agents, these benefits however have not been replicated in clinical trials, necessitating a further search for more promising anti-inflammatory agents. Current understanding highlights the role of diet in the development of neuroinflammation and oxidative stress, as well as the importance of dietary interventions and lifestyle modifications in mitigating them. The current narrative review examines scientific literature for evidence of the roles if any of dietary components, nutraceuticals and functional foods in the prevention or management of AD. It also examines how diet/dietary components could modulate oxidative stress/inflammatory mediators and pathways that are crucial to the pathogenesis and/or progression of AD.
OLOFINNADE ANTHONY is a Lecturer I at the Department of Pharmacology
OLOFINNADE has a Ph.D in Pharmacology from Ladoke Akintola Universaity of Technology