OLOFINNADE ANTHONY TOPE

Pharmacology

At the Pharmacology department office

Appointment on Visitation important

Topic: Neurobiological Changes In Autism Spectrum Disorders: A Review Of Current Literature

Description:

Background: Autism spectrum disorder (ASD) is an array of neurodevelopmental disorders that are characterised by the presence of cognitive and neurobehavioural deficits. Although the aetiology of ASD remains a mystery, its aetiopathogenesis has been attributed to genetic and non-genetic factors More recently, advances in clinical and preclinical research are also providing evidence of neurobiological and neuroanatomical changes in ASD  Objectives: In this narrative review we discuss recent advances in our understanding of the neuroanatomical, neurobiological and neuropathological processes associated with ASD; with a view to relating clinical symptomatology with anatomical changes. Also examined is the impact of these advances on treatment options and health outcomes  Strategy: This review examined extant literature to provide a comprehensive update on the relationship between neurobiological factors and ASD.

#	Certificate	School	Year
1.	Ph.D (Pharmacology)	Ladoke Akintola Universaity of Technology	2022

Neuroinflammation and oxidative stress in Alzheimer's disease; Can nutraceuticals and functional foods come to the rescue?

Alzheimer's disease (AD), the most prevalent form of age-related dementia, is typified by progressive memory loss and spatial awareness with personality changes. The increasing socioeconomic burden associated with AD has made it a focus of extensive research. Ample scientific evidence supports the role of neuroinflammation and oxidative stress in AD pathophysiology, and there is increasing research into the possible role of anti-inflammatory and antioxidative agents as disease modifying therapies. While, the result of numerous preclinical studies has demonstrated the benefits of anti-inflammatory agents, these benefits however have not been replicated in clinical trials, necessitating a further search for more promising anti-inflammatory agents. Current understanding highlights the role of diet in the development of neuroinflammation and oxidative stress, as well as the importance of dietary interventions and lifestyle modifications in mitigating them. The current narrative review examines scientific literature for evidence of the roles (if any) of dietary components, nutraceuticals and functional foods in the prevention or management of AD. It also examines how diet/dietary components could modulate oxidative stress/inflammatory mediators and pathways that are crucial to the pathogenesis and/or progression of AD.

OLOFINNADE ANTHONY is a Lecturer I at the Department of Pharmacology

OLOFINNADE has a Ph.D in Pharmacology from Ladoke Akintola Universaity of Technology