Meet OLARIBIGBE FUNMILAYO KAWTHAR, an Academic Staff of Lagos State University.
Reproductive Physiology
Graduate Assistant
Physiology
At the Physiology department office
Appointment on Visitation important
| # | Certificate | School | Year |
|---|---|---|---|
| 1. | M.Sc (Physiology) | Lagos State University | 2024 |
EFFECTS OF KIGELIA AFRICANA FRUIT EXTRACTS ON THE CONTRACTILE ACTIVITY OF CORPUS CAVERNOSUM IN MALE RABBITS
Introduction: Kigelia have been reported to enhance male fertilityAim: This study investigated the effect of K .africana fruit extracts on the contractile activity of the corpus cavernosa using different agonists. Methodology: Corpus cavernosum strips from six healthy male New Zealand rabbits 2.5-3.0 kg were mounted on an organ chamber and pre-contracted with phenylephrine PHE 10-7M and potassium chloride KCl 10 mM before treatment with various concentrations of aqueous and ethanol KAFE 0.1-0.6 g/mL . Corpus cavernosum relaxation response evoked by aqueous and ethanol KAFE was investigated in the absence and presence of oxalodiazolo 4,3-a quinoxalin-1-one- ODQ 10 M ; a guanylyl cyclase inhibitor, potassium channel inhibitiors; tetra ethyl ammonium TEA 1mM , ondansetron 10-4M , glibenclamide, 20 M , and barium chloride 30 M . Results: The response to PHE was reduced from 67.7% to 46.5% and 62.6 % to 35.6 % for aqueous and ethanol KAFErespectively. The response to KCl was reduced from 64.6% to 35.0 % and 68.7 % to 32.7 % for aqueous and ethanolKAFE respectively. At maximum doses of the extract, ODQ has no significant p0.05 effect on the relaxation response for both aqueous and ethanol KAFE. TEA significantly reduced p 0.05 corpus cavernosum relaxation response to aqueous KAFE, however at maximum dose of the extract TEA had no significant p& 0.05 effect on the relaxation response of ethanol KAFE. Glibenclimide significantly reduced p& 0.05 aqueous KAFE induced cavernosum relaxation, but not at maximum doses of doses of ethanol KAFE p & 0.05 .The corpus cavernosum relaxation response in the presence of Barium chloride were also significantly p& 0.05 reduced for all doses except the maximum dose for both aqueous and ethanol KAFE. Conclusion: These results suggests that the relaxant activity of aqueous and ethanol K. africana extracts on corpus cavernosum induced contractions entail the soluble guanylate cyclase/cyclase Guanosine monophosphate system and triggering of potassium channels.
OLARIBIGBE KAWTHAR is a Graduate Assistant at the Department of Physiology
OLARIBIGBE has a M.Sc in Physiology from Lagos State University
