OLAJIDE ABIMBOLA MOFOLUWASO

Oral Pathology / Oral Medicine

At the Oral Pathology / Oral Medicine department office

Appointment on Visitation important

Topic: Diagnostic Criteria For Ameloblastic Carcinoma

Description: Ameloblastic carcinoma is generally a rare odontogenic malignancy. However, a number of jaw tumours that presented at Lagos State University Teaching Hospital in the last 7 years were histologically diagnosed as Ameloblastic Carcinoma. This study aims at proposing standard diagnostic criteria for this rare malignancy based on the cases seen. The study method will be case series report and a systematic review of literature.

#	Certificate	School	Year
1.	Bachelor of Dental Surgery BDS (Dentistry)	University of Lagos	2002

Concordance and Discordance of Clinical and Histopathological Diagnoses

Introduction-The art of establishing a clinical or differential diagnosis requires knowledge, clinical expertise, and the ability to create mental pathways that lead to a definitive diagnosis. This diagnostic reasoning process involves integrating the patient's medical history, the history of the presenting complaint, and the observed clinical manifestations. Histopathologic examination remains the gold standard, particularly for unresolved or clinically suspicious lesions. Therefore, a biopsy is often indicated in oral and maxillofacial lesions for a definitive diagnosis to rule out or confirm clinical impression or differential diagnosis.

This study aimes to evaluate the concordance between the clinical and histopathologic diagnoses of biopsied soft-tissue specimens submitted to the Oral Pathology Biopsy Service of the Lagos State University Teaching Hospital/Lagos State University College of Medicine over a 15-year period.

Methods

The clinical and histopathological diagnoses would be classified based on harmonized nomenclature and synonyms. All the diagnoses would then be classified according to their pathogenesis. The outcome measurement will be the percentage of absolute concordance, relative concordance, and discordance. Diagnostic agreement will be evaluated using Cohen’s kappa; sensitivity, specificity, and positive and negative predictive values (PPV and NPV, respectively) will be  calculated. The relationship between patient's gender, age group, pathogenic-cluster, type of biopsy, biopsy technique, requesting clinician's specialty, clinician's experience, gender of clinician, experience of pathologist and  concordance will be tested using the Chi-square test or the Sample t-test,as indicated.

OLAJIDE MOFOLUWASO is a Senior Lecturer at the Department of Oral Pathology / Oral Medicine

OLAJIDE has a Bachelor of Dental Surgery BDS in Dentistry from University of Lagos