OLAJIDE MOFOLUWASO ABIMBOLA

Oral Pathology / Oral Medicine

At the Oral Pathology / Oral Medicine department office

Appointment on Visitation important

Topic: SERIAL IMMUNE RESPONSE INDICES IN SYMPTOMATIC COVID -19 PATIENTS

Description:

Background: Coronavirus disease 2019 (COVID-19) is defined as an illness caused by a novel coronavirus now called Severe Acute Respiratory Syndrome.

While majority of people with COVID 19 infection are asymptomatic, others come down with a range of mild to moderate symptoms with eventual recovery, or severe life threatening infection leading to fatality.

It is pivotal to investigate the adaptive immune response to COVID- 19 in the Nigerian population, by serial antibody and cellular immunity assessments, since there is a dearth of scientific information from Africa generally, on our pattern of immune response to COVID-19.

Aim: To determine effect of  serial serum levels of immune response indices on the severity of the COVID-19 infection

 Methodology: This is a population and Isolation- treatment centre based longitudinal observational (cohort) study that will be conducted in  selected state isolation/ treatment centres and an approved COVID-19 testing laboratory, as well as the general population of the selected Nigerian states. 

Expected Result: to establish that adequate combined adaptive immune response shown by the levels of immune system parameters correlate inversely with the severity of COVID-19 symptoms. It is also expected to show the quantified levels of immunity conferred on convalescent (recovered) COVID-19 infected individuals, up to 30 days post recovery.

Impact: It will add to the much needed global evidence on, the length of protective immunity conferred on previously COVID-19 infected and convalescent (recovered) individuals, based on post recovery time.

#	Certificate	School	Year
1.	Bachelor of Dental Surgery(BDS) (Dentistry)	University of Lagos	2002

CLINICOPATHOLOGIC PROFILE OF ORAL SQUAMOUS CELL CARCINOMA (OSCC) AND SINONASAL SQUAMOUS CELL CARCINOMA(SNSCC).

Background: Oral Squamous Cell Carcinoma is said to be the most common malignancy affecting the oral cavity while Squamous cell carcinoma of the sinonasal tract is less common. Changing patterns have been observed in the incidence of these lesions in recent years.

Objective:

This study aims to determine the demographics, clinical and histopathologic characteristics of Oral Squamous Cell carcinoma and Sinonasal Squamous Cell Carcinoma in a Nigerian (African) population over a period of 7 years (2013 to 2019).

Materials and Methods:

In this retrospective study, records from the archives of the Oral Pathology laboratory, Faculty of Dentistry, Lagos State University College of Medicine over a period of 7 years (2013 to 2019) were reviewed to retrieve the age, sex, site, grade and variant (where indicated) of cases. Data was analyzed using SPSS (version 20).

Results:

The prevalence of OSCC in our study was 34.5% of all oral and maxillofacial malignancies, while SNSCC accounted for 5.5%. Mean age for OSCC was 56.5(SD±16.4) years, while that of SNSCC was 47.0 (SD±9.23) years. These lesions were more frequent in males (63.2% and 66.7% for OSCC and SNSCC respectively) than females. The most common site of involvement in OSCC was the tongue (28.9%). 66.7% of the SNSCC was the Keratinising type. 75% of  Keratinising SNSCC  and 55.3% of OSCC were graded moderately differentiated.

Conclusion: 

Incidence and distribution of these lesions in the light of new adaptations of cultural practices will help to identify existent patterns for diagnosis in Africans.

OLAJIDE MOFOLUWASO is a Lecturer I at the Department of Oral Pathology / Oral Medicine

OLAJIDE has a Bachelor of Dental Surgery(BDS) in Dentistry from University of Lagos