At the Chemical Pathology department office
Appointment on Visitation important
|1.||Fellowship of the Medical College (Pathology( Chemical Pathology))||National Postgraduate Medical College of Nigeria||2017|
The Relationship between Plasma Lipoprotein Lipase activity and Glycaemic control in Tpe 2 Diabetic Patients.
Diabetes Mellitus(DM) is a metabolic disorder characterized by chronic hyperglycaemia, due to insulin deficiency and or resistance. Insulin is a regulatory hormone of glucose metabolism and it also has a stimulatory effect on Lipoprotein Lipase(LPL) activity. Furthermore, insulin resistance has been associated with dyslipidaemia in type 2 Diabetes Mellitus(T2DM).
LPL activity has been proven to be decreased in T2DM causing hypertriglyceridaemia and elevated Low Density Lipoprotein Cholesterol(LDL-C). These play an important role in the pathogenesis of Cardiovascular Diseases.
This study was designed to find the relationship between plasma LPL activity and glycaemic control in T2DM.
It is a descriptive cross-sectional study conducted between January to March 2017. A total of 166 T2DM participants and 166 apparently healthy and age-matched controls were included in the study.
LPL activity, Glycated haemoglobin (HbA1c), High Density Lipoprotein Cholesterol (HDL-C), Plasma Total Cholesterol(TC), Triglyceride (TG), Low Density Lipoprotein Cholesterol(LDL-C) in the subjects and control groups were analyzed.
Diabetics had a significant elevation of TC of 185.7±45.1, LDL-C 142.0±43.5 and HbA1c level of 8.3±2.4. The LPL activity was 57.3±3.7 which was significantly lower in this group. There was a relationship between plasma LPLactivity and glycaemic control in type 2 diabetes.
These findings may suggest that T2DM
is associated with reduced activity of LPL enzyme which plays an
an important role in lipid metabolism and dyslipidaemia with an increased
risk of cardiovascular diseases.
OKUNOWO LANREWAJU is a Lecturer I at the Department of Chemical Pathology
OKUNOWO has a Fellowship of the Medical College in Pathology( Chemical Pathology) from National Postgraduate Medical College of Nigeria