OJO TUNDE OLUWAFEMI

Medicine

At the Medicine department office

Appointment on Visitation important

Topic: Clinical Evolution Of Respiratory Outcomes In Adult TB Patients Introduction

Description: Nigeria ranked sixth among the 30 high TB burden countries globally and 1st in Africa 1, 2 . In 2021, the estimated TB incidence in Nigeria was 467,000 3 . There was an estimated death of 125,000 people from the disease that year 3 . Lagos has about 10% of the burden of TB in Nigeria 4, 5 . Despite the availability of treatment, there exists significant morbidity and mortality even after treatment 6, 7 . Globally, it has been estimated that up to half of all former TB patients are left with post-TB lung disease PTLD at the end of TB treatment 8-10 . The incidence of post-TB lung disease in Lagos is 6.1% 11 .JustificationThere are a few data on estimates of the frequency of respiratory outcomes on medium and long term after PTB treatment completion in West Africa. There remains no standardised guidelines for the diagnosis and management of PTLD. 8, 12 This study will help to identify patients at risk of adverse respiratory outcomes that will benefit from appropriate post-TB care.Research questionWhat are the respiratory outcomes in adult pulmonary TB patients on DOTS treatment at selected TB treatment centres in Lagos, Nigeria?HypothesisThere is no significant adverse respiratory outcome in Adult PTB patients enrolled in DOTS treatment programAims/ObjectivesTo assess the frequency of respiratory symptoms in TB patients at treatment completion, and 6 months post treatmentTo assess radiological changes in TB patients on treatment during the same periodTo assess the spirometric parameters of TB patients on treatment during same period. To assess the exercise tolerance with 6 minutes walk test of TB patients on treatment during same period.MethodsDesign-Prospective cohort studySite- DOTS centers in Ikeja local government,Lagos Population- Drug susceptible TB patients on programmatic Treatment.Inclusion criteriaPatient from 15years and above on TB treatmentPatients enrolled at any Ikeja DOTS centerPatient with baseline CXRExclusion- Patient with active TB and concomittant acute respiratory infectionsPatients that do not grant consentTB Patient not on programmatic treatment Sample size- 220 based on incidence rate of 6.1%, assumed relative risk of 3, confidence of 95% and desired power of 0.8Sampling method simple random samplingExposureTB infection- Pulmonary tuberculosis OutcomesPresence of Cough, shortness of breath, wheeze, hemoptysis and sputum expectorationFEV1, FVC, FEV1/FVC, PEFBaseline oxygen saturationDistance covered during six minutes walkData collectionUse of profoma to obtain socio-demographic information and respiratory symptoms using IMPALA/St Georges questionnaire at completion of treatment, and 6 months post treatment.CRX for the same period of timeSpirometry data for the same period of timeSix minutes walk test for the same period of timeData managementProformal data will be collected using goggle formCXR findings with be inputted on excel sheetSpirometry data will also be inputted on excel sheetSix minutes walk data will also be inputted on excel sheetAnalysisDescriptive statistics FrequenciesPercentagesMedian, interquartile rangeInferential statistics will also be done Ethical approvalEthical approval will be obtained from ethical committee of Lagos State University Teaching Hospital.

#	Certificate	School	Year
1.	FWACP (INTERNAL MEDICINE/PULMONOLOGY)	WEST AFRICAN COLLEGE OF PHYSICIAN	2018

CLINICAL CHARACTERISTICS OF LUNG CANCER PATIENTS IN LAGOS STATE UNIVERSITY TEACHING HOSPITAL

Lung cancer is a growing concern worldwide and a leading cause of cancer-related deaths. Tobacco smoking has been reported to be the most significant risk factor for the development of lung cancer as the incidence of lung cancer rises with increased smoking rates, nevertheless, some cases occur in individuals who have never smoked.The true incidence of lung cancer in Nigeria is not known, however, hospital-based studies have reported an increasing incidence.Currently, no study has documented the clinical profile of lung cancer patients seen in LASUTH despite it being a major cancer in Nigeria. There is also no harmonized registry of lung cancer patients in various clinics. This study aims to describe the clinical patterns of lung cancer patients attending Lagos State University Teaching Hospital. The findings from this study will assist in identifying the common presentations and clinic-pathological profile of lung cancer patients in LASUTH and facilitate diagnosis and case management in the hospital. It will also elucidate the need for the hospital management to come up with policies that will aid the creation of a lung cancer registry.

OJO OLUWAFEMI is a Senior Lecturer at the Department of Medicine

OJO has a FWACP in INTERNAL MEDICINE/PULMONOLOGY from WEST AFRICAN COLLEGE OF PHYSICIAN