OJEWALE ABDULFATAI OLAKUNLE

Anatomy

At the Anatomy department office

Appointment on Visitation important

Topic: Endocrinology And Reproductive Biology

Description:

Contributions to the areas of endocrinology, reproductive biology, physical anthropology, nutraceutical, and alternative medicine.

#	Certificate	School	Year
1.	Ph.D (Endocrine and Reproductive Anatomy)	Olabisi Onabanjo University, Ago-Iwoye, Ogun, Nigeria	2019

Mitigating roles of Ethanolic Roots Extract of Ageratum conyzoides on Blood Glucose, Lipid Profile, Insulinotropic activities, and on Pancreatic Beta changes Cells in Alloxan-Induced Diabetic Rats

Aim: The  study  investigated  the  modulating  roles  of  ethanolic  roots  extract  of Ageratum conyzoides for  its antihyperglycemic, antihyperlipidemic, insulinotropic activities  and on pancreatic  beta  cells changes  in  alloxan-induced diabetic rats. Methodology: Twenty Wistar rats were randomly divided into four  (4) experimental groups: control, diabetic,  and A. conyzoides (250 and 500 mg/kg bwt) treated diabetic groups The animals in three out of  four  groups  were  fasted  for  18  h  and  were  made  diabetic  by  injecting  with  a  single dose of alloxan (ALX) 150 mg/kg, Diabetic rats 5 per group received graded doses (250 and 500 mg/kg bwt) of the extracts for 28 days. Blood was collected every week for four weeks for  glucose  estimation. Lipid  profile  was  measured using  DiaSys  Kits  from  Germany  which  utilized  the  colorimetric  method.  Insulin Assay was measured using Monobind Insulin Microplate Elisa test.
Diabetic  rats  without  treatment  showed  significant  increases  (p<0.05)  in  the  levels  of blood  glucose,  triglycerides,  total  cholesterol,  low  density  lipoprotein  LDL-cholesterol while  the  high  density  lipoprotein  HDL-cholesterol  level  were  significantly  decreased(p<0.05) compared to normal rats. In addition, the diabetic rats treated with the Ageratum conyzoides showed  significant  decrease  (p<0.05)  in blood glucose,  TG  and  LDL cholesterol levels and a significant decrease (p<0.05) in HDL cholesterol level compared to  diabetic  untreated  rats.  There were  significant  reductions  (p<0.05)  in low-density lipoprotein  (LDL)-cholesterol  levels  and  significant  increase  (p<0.05)  in  the treated diabetic group compared to the negative control. In addition, cytoarchitectural changes  also  revealed  the  protective  nature  of  the ethanolic roots extract of  Ageratum conyzoides against  alloxan  induced necrotic damage of pancreatic tissues.

The ethanolic  roots  extract  of Ageratum conyzoides mitigated hyperglycemic  by  stimulating insulin release from the beta cells of the pancreas  and attenuated dyslipidemia.

It contributes to the areas of experimental and clinical endocrinology, nutraceutical and alternative medicine.

OJEWALE ABDULFATAI is a Lecturer II at the Department of Anatomy

OJEWALE has a Ph.D in Endocrine and Reproductive Anatomy from Olabisi Onabanjo University, Ago-Iwoye, Ogun, Nigeria