Endocrine And Reproductive Anatomy
At the Anatomy department office
Appointment on Visitation important
Topic: Endocrinology And Reproductive Biology
Contributions to the areas of endocrinology, reproductive biology, physical anthropology, nutraceutical, and alternative medicine.
|1.||Ph.D (Endocrine and Reproductive Anatomy)||Olabisi Onabanjo University, Ago-Iwoye, Ogun, Nigeria||2019|
Mitigating roles of Ethanolic Roots Extract of Ageratum conyzoides on Blood Glucose, Lipid Profile, Insulinotropic activities, and on Pancreatic Beta changes Cells in Alloxan-Induced Diabetic Rats
Aim: The study investigated the modulating roles of ethanolic roots extract of Ageratum conyzoides for its antihyperglycemic, antihyperlipidemic, insulinotropic activities and on pancreatic beta cells changes in alloxan-induced diabetic rats. Methodology: Twenty Wistar rats were randomly divided into four (4) experimental groups: control, diabetic, and A. conyzoides (250 and 500 mg/kg bwt) treated diabetic groups The animals in three out of four groups were fasted for 18 h and were made diabetic by injecting with a single dose of alloxan (ALX) 150 mg/kg, Diabetic rats 5 per group received graded doses (250 and 500 mg/kg bwt) of the extracts for 28 days. Blood was collected every week for four weeks for glucose estimation. Lipid profile was measured using DiaSys Kits from Germany which utilized the colorimetric method. Insulin Assay was measured using Monobind Insulin Microplate Elisa test.
Diabetic rats without treatment showed significant increases (p<0.05) in the levels of blood glucose, triglycerides, total cholesterol, low density lipoprotein LDL-cholesterol while the high density lipoprotein HDL-cholesterol level were significantly decreased(p<0.05) compared to normal rats. In addition, the diabetic rats treated with the Ageratum conyzoides showed significant decrease (p<0.05) in blood glucose, TG and LDL cholesterol levels and a significant decrease (p<0.05) in HDL cholesterol level compared to diabetic untreated rats. There were significant reductions (p<0.05) in low-density lipoprotein (LDL)-cholesterol levels and significant increase (p<0.05) in the treated diabetic group compared to the negative control. In addition, cytoarchitectural changes also revealed the protective nature of the ethanolic roots extract of Ageratum conyzoides against alloxan induced necrotic damage of pancreatic tissues.
The ethanolic roots extract of Ageratum conyzoides mitigated hyperglycemic by stimulating insulin release from the beta cells of the pancreas and attenuated dyslipidemia.
It contributes to the areas of experimental and clinical endocrinology, nutraceutical and alternative medicine.
OJEWALE ABDULFATAI is a Lecturer II at the Department of Anatomy
OJEWALE has a Ph.D in Endocrine and Reproductive Anatomy from Olabisi Onabanjo University, Ago-Iwoye, Ogun, Nigeria