Meet OGUNTONA TAIWO SHOLA, an Academic Staff of Lagos State University.
Medicinal Plants, Diabetic Nephrooathy
Lecturer I
Medical Biochemistry
At the Medical Biochemistry department office
Appointment on Visitation important
Topic: RENAL FIBROSIS
Description: Chronic Kidney Disease CKD is an incurable disease with so much medical and financial burden on individual and the society. CKD is characterized with accumulation of Extracellular matrix ECM which leads to fibrosis of the kidney and End Stage Renal Disease ESRD . Carboxypeptidase B2 is a key player in renal fibrosis and previous studies have reported that inhibition of Carboxypeptidase B2 improves renal function and survival in diabetic nephropathy. We therefore seek to test this in animal models with a more relevant metabolic drive over a prolonged treatment period, establish relevance to man and ascertain how manipulation of this pathway affects matrix metalloproteinase activation. This would entail: 1 Animal model and Assays.2 Blood glucose analysis and insulin therapy3 Renal function test Urea, BUN, Creatinine, and proteinuria. 4 Assessment of scaring index, ECM proteolysis level, inflammation, and fibroblast proliferation.5 Carboxypeptidase B2 and Plasmin activity in CKD patients.
| # | Certificate | School | Year |
|---|---|---|---|
| 1. | Ph.D () | The University of Sheffield | 2018 |
Inducing Diabetic Nephropathy in Male Wistar Albino Rat using a Two -Step approach of Nephrectomy and streptozotocin injection
Renal injury is a known cause of Diabetic nephropathy DN which is characterized by the build-up of extracellular matrix ECM . In DN the renal architecture is disrupted and there is also loss of renal function. We hypothesized that Diabetic nephropathy can be induced with both nephrectomy and type 1 diabetics An in vivo rat model of DN was used. Unilateral nephrectomy and induction of type 1 diabetes with 40mg/kg streptozotocin in 2 repeated doses. Blood glucose was maintained between 360-450 mg/dl for 6 months with linplants. The rats were divided into 2 groups. Group 1 control . Group 2 disease had nephrectomy and type1 diabetic induced. Our results confirmed DN in this rat model.
OGUNTONA TAIWO is a Lecturer I at the Department of Medical Biochemistry
OGUNTONA has a Ph.D in from The University of Sheffield
