Molecular Drug Metabolism And Toxicology
At the Biochemistry department office
Appointment on Visitation important
|M. Phil. (Molecular Drug Metabolism and Toxicology)
|Biochemistry Department, University of Ibadan, Ibadan, Oyo State, Nigeria.
Role of Momordica charantia Extract in Prevention of Colorectal Cancer in Experimental Mice Model
Studies have shown that globally, colorectal cancer CRC is the third and second most commonly diagnosed cancer in males and females, respectively with increasing annual incidence and over 160,000 mortality. In Nigeria, CRC is a major form of cancer in men and women with peak occurrence from 51 to 60 years and 41 to 50 years, respectively. Sex-disparities do occur in tumour sites in CRC patients, possibly due to hormonal effects, thereby leading to higher mortality in women above 65 years and lower five-year survival than age-matched men. Causal factors for colorectal cancer development include dietary, lifestyle and environmental agents e.g. polycyclic aromatic hydrocarbons . Overtime, attention has been drawn to dietary regimens and natural agents as management alternatives to many of the available cancer management therapies. Among notable wild herbs, Momordica charantia reportedly shows promising medicinal potential and efficacy in management of various disorders, using experimental animal models. Results from experimental studies reveal that crude solvent extracts especially ethanolic fraction of this plant possess high anti-inflammatory, anti-tumour and body weight modulatory effects when administered to experimental animals at low doses. This study aims to determine tumour reduction and CRC-preventive role of Momordica charantia leaf extract on benzo a pyrene/dextran sulphate sodium-induced colorectal cancer in male and female mice. Further analysis will be performed on the extract to determine/isolate component with optimal bochemical effect. Occult blood screening, hormonal assays, inflammatory markers and cytokines/protein levels and/or expressions, using spectrophotometry, microscopy, ELISA, SDS-PAGE, etc. The plant extract should delay and/or prevent CRC development in experimental mice to be used and that results obtained might make the plant to be potentially relevant as cheap dietary supplement for CRC prevention and/or possibly cure.
OGUNGBE BIMPE is a Lecturer I at the Department of Biochemistry
OGUNGBE has a M. Phil. in Molecular Drug Metabolism and Toxicology from Biochemistry Department, University of Ibadan, Ibadan, Oyo State, Nigeria.