Organic And Natural Product Chemistry
At the Chemistry department office
Appointment on Visitation important
Topic: NATURAL PRODUCTS CHEMISTRY, MEDICINAL PLANTS ANALYSIS AND LIFE SCIENCES.
(i) Identification, purification and structural elucidation of potential bioactive compounds in plant materials that may be of importance for the promotion of health. (ii) Isolation of volatiles from plant sources by conventional methods and characterization of their aroma and flavour constituents. (iii) Evaluation of the pharmacological potentials of plant materials and implementation of in vitro and in vivo assays for bioassay-guided fractionation of plant extracts for assessment of IC50, LD50 and ED50 values of isolated compounds
|1.||Ph.D (Chemistry/ Organic and Natural Product Chemistry)||University of Ibadan, Ibadan Nigeria||2014|
Volatile and Non-volatile Chemical Compositions of Selected Nigerian Medicinal Plants and their Medicinal Potentials
Introduction: Plants, animals and micro-organisms represent a reservoir of natural products, which are natural sources deriving compounds. Particularly, plant kingdom offers a variety of natural products species still used as remedies for several diseases in many parts of the world.
Aims/Objectives: The on-going research investigate the Isolation, characterization and Pharmacological activities of Volatile and Non-volatile chemical constituents from selected Nigerian medicinal plants
Methodology: Plant samples will be selected based on the ethnomedicinal information. Plant material will be extracted using cold extraction method. The isolation an of bioactive components shall be done using chromatography techniques. The Volatile constituents of the plant samples will be distilled using a modified Clevenger-type apparatus. The structure of isolated constituents shall be determined using spectroscopic techniques while the volatile constituents shall be identified using GC-MS analysis. Antioxidant, antimicrobial, antidiabetics and cytotoxicity potentials of the chemical constituents will be carried out according to the standard procedures
Expected Results: The antioxidant, antidiabetic, antimicrobial and cytotoxicity potentials of extracts and volatile oils at the tested concentrations will be determined while phytochemicals responsible for the activities will also be identify.
Contribution to Knowledge: The chemical constituents that will be identified will serve as future lead drugs. Newly Isolated compounds will increase the Library of Natural Products
OGUNDAJO AKINTAYO is a Senior Lecturer at the Department of Chemistry
OGUNDAJO has a Ph.D in Chemistry/ Organic and Natural Product Chemistry from University of Ibadan, Ibadan Nigeria