ODUYEMI AISHA OLUWATOSIN

Physiology

At the Physiology department office

Appointment on Visitation important

#	Certificate	School	Year
1.	Ph.D (Reproductive and Neuroendocrine Physiology)	University of Ibadan	2025

Erectogenic Mechanisms of Carpolobia lutea (G. DON) Root Methanol Extract in Male New Zealand Rabbit with Paroxetine-induced Erectile Dysfunction

Erectile dysfunction (ED) remains a major global reproductive health concern affecting male fertility and quality of life. Among its diverse causes, the use of selective serotonin reuptake inhibitors (SSRIs) such as paroxetine is a well-documented contributor to Paroxetine-induced sexual dysfunction. Current pharmacological treatments for ED, like phosphodiesterase-5 inhibitors, are limited by side effects and contraindications, underscoring the need for safer and more sustainable alternatives. Carpolobia lutea root, a plant widely used in traditional medicine, has been reported to possess aphrodisiac and fertility-enhancing properties, yet its mechanistic basis has not been fully elucidated.

This study aimed to evaluate the ameliorative effects of Carpolobia lutea root extract (CLRE) on Paroxetine-induced erectile dysfunction in male rabbits and to explore the mechanisms underlying its erectogenic action.

The specific objectives were to:

1. Assess the effect of CLRE on penile reflexes and erectile responses following paroxetine administration.
2. Determine the influence of CLRE on hormonal profiles (testosterone, LH, and FSH).
3. Investigate the involvement of the NO/cGMP pathway, potassium channels, prostaglandins, and serotonergic modulation in CLRE’s action.
4. Analyze the phytochemical constituents responsible for its pharmacological activity.

Methodologically, the study employed a controlled experimental design using adult male rabbits divided into treatment groups. Erectile responses were measured following corpus cavernosum stimulation, while biochemical assays and receptor pathway modulators (e.g., L-NAME, indomethacin, ondansetron) were used to delineate underlying mechanisms.

It is expected that CLRE will ameliorate Paroxetine-induced erectile dysfunction by enhancing NO/cGMP signaling, modulating serotonergic and prostaglandin pathways, and improving testosterone availability, supporting its potential as a natural therapeutic agent for sexual dysfunction.

 

ODUYEMI OLUWATOSIN is a Assistant Lecturer at the Department of Physiology

ODUYEMI has a Ph.D in Reproductive and Neuroendocrine Physiology from University of Ibadan