At the Pharmacology department office
Appointment on Visitation important
Topic: Drug Development And Clinical Trials
Areas of research interest also include drug development. Many herbal extracts with therapeutic claims are administered for across this region without the appropriate evidence-based research studies being conducted on them.
Therefore, the use of traditional medicine in disease treatment can be dissected, commencing from toxicology studies in animal models to pre-experimental models of the disease, concluding with various phases of clinical trials.
|1.||Ph.D (Medical Biosciences)||University of Bradford||2008|
Apigenin and Apigeninidin isolates from the sorghum bicolor leaf targets inflammation via cyclo-oxygenase-2 and prostaglandin - E2 blockade
INTRODUCTION AND AIMS: This study evaluated the anti-inflammatory properties of a species of sorghum bicolor leaf (SBL) grown in West Africa.
METHODOLOGY: Cyclo-oxygenase (COX) -2: COX1 selectivity assay was carried out by plating isolated peripheral blood mononuclear cells in culture with specific SBL fractions: crude extract (J); ethyl-acetate (JE); aqueous (JA); secondary compounds from JE (JE5, JE6, JE7 and JE8); purified P9 and semi-purified P8 compounds from JE5 at 5-200ug/ml for 1hr. Test compounds and control Ibuprofen (50umol/L) and CAY10404 (1 and 10umol/L) were added to 2 sets of plates, one without lipopolysaccharide (LPS) and the other with LPS (1ug/mL) for 24hrs. COX-2IC50:COX-1IC50 ratio represented 50% inhibition of the activity of COX-2 to that of COX-1 using Ibuprofen as a control.
OUTCOME: JA fraction of SBL had the highest ratio of COX-2IC50: COX-1IC50 41.214 while P8 derived from JE5 showed a dose-dependent reduction in COX-2IC50:COX-1IC50 ratio and in the PG-E2 production, which was more effective compared to Ibuprofen
MAKANJUOLA SAMIRA is a Senior Lecturer at the Department of Pharmacology
MAKANJUOLA has a Ph.D in Medical Biosciences from University of Bradford