MAKANJUOLA SAMIRA BATISTA LOBO

Meet MAKANJUOLA SAMIRA BATISTA LOBO, an Academic Staff of Lagos State University.

Specialization

Designation

Senior Lecturer

Department

Pharmacology

Office

At the Pharmacology department office

Visiting Hour

Appointment on Visitation important

Research Interest

Topic: Drug Development And Clinical Trials

Description:

Areas of research interest also include drug development. Many herbal extracts with therapeutic claims are administered for across this region without the appropriate evidence-based research studies being conducted on them.

Therefore, the use of traditional medicine in disease treatment can be dissected, commencing from toxicology studies in animal models to pre-experimental models of the disease, concluding with various phases of clinical trials. 

Qualifications

# Certificate SchoolYear
1. Ph.D (Medical Biosciences) University of Bradford 2008

Current Research

Apigenin and Apigeninidin isolates from the sorghum bicolor leaf targets inflammation via cyclo-oxygenase-2 and prostaglandin - E2 blockade

Research Details

INTRODUCTION AND AIMS: This study evaluated the anti-inflammatory properties of a species of sorghum bicolor leaf (SBL) grown in West Africa.

METHODOLOGY: Cyclo-oxygenase (COX) -2: COX1 selectivity assay was carried out by plating isolated peripheral blood mononuclear cells in culture with specific SBL fractions: crude extract (J); ethyl-acetate (JE); aqueous (JA); secondary compounds from JE (JE5, JE6, JE7 and JE8); purified P9 and semi-purified P8 compounds from JE5 at 5-200ug/ml for 1hr. Test compounds and control Ibuprofen (50umol/L) and CAY10404 (1 and 10umol/L) were added to 2 sets of plates, one without lipopolysaccharide (LPS) and the other with LPS (1ug/mL) for 24hrs. COX-2IC50:COX-1IC50 ratio represented 50% inhibition of the activity of COX-2 to that of COX-1 using Ibuprofen as a control.

OUTCOME: JA fraction of SBL had the highest ratio of COX-2IC50: COX-1IC50 41.214 while P8 derived from JE5 showed a dose-dependent reduction in COX-2IC50:COX-1IC50 ratio and in the PG-E2 production, which was more effective compared to Ibuprofen

Biography

MAKANJUOLA SAMIRA is a Senior Lecturer at the Department of Pharmacology

MAKANJUOLA has a Ph.D in Medical Biosciences from University of Bradford

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