KAZEEM IDOWU MUTIU

Biochemistry

At the Biochemistry department office

Appointment on Visitation important

Topic: MEDICAL BIOCHEMISTRY: PHYTOTHERAPEUTICS FOR DIABETES AND METABOLIC DISORDERS

Description: Diabetes mellitus is a metabolic disorder characterized by alterations in carbohydrate, fats and protein metabolism that results from defects in insulin secretion or insulin action. The number of people suffering from the disease worldwide is increasing at an alarming rate with a projected 700 million people likely to be diabetic by the year 2045 as against 463 million estimated in 2019. The management of diabetes mellitus is considered a global problem and successful treatment is yet to be discovered. The underlying goal of all diabetes management is to maintain an adequate blood glucose concentration. The main approach used in the management of diabetes is oral hypoglycemic drugs such as biguanides metformin , sulfonylureas glimepiride , thiazolidinediones pioglitazone and alpha-glucosidase inhibitors acarbose . However, these drugs have been shown to have undesirable side effects and high secondary failure rates. In addition, they cannot be afforded by majority of people living in rural communities of developing countries because of their high cost. These limitations of currently available antidiabetic agents have prompted researchers all over the world to investigate alternative antidiabetic remedies. The main thrust of my research is the evaluation of medicinal foods and plants for their antidiabetic potential using both in-vitro and in-vivo methods. The in-vitro technique involves the determination of the inhibitory potentials of plant extracts on the activities of diabetes-related enzymes alpha-amylase, alpha-glucosidase, aldose reductase and sorbitol dehydrogenase . The in-vivo method encompasses the use of animals e.g Wistar rats in the evaluation of the possible antidiabetic properties of the medicinal plants.

#	Certificate	School	Year
1.	Ph.D (Biochemistry)	University of Ilorin, Ilorin, Nigeria	2012

ANTIDIABETIC AND ANTI-AGEING PROPERTIES OF SELECTED PHYTOCHEMICALS IN DROSOPHILA MELANOGASTER

BACKGROUND: Diabetes mellitus is a chronic condition characterized by hyperglycemia due to defects in insulin secretion and/or insulin action. The prevalence of diabetes, especially type 2 diabetes, increases with age, with the majority of people globally who have diabetes being over 64 years old. Dysfunction of multiple organ systems manifests similarly in diabetes as it does during normal chronological ageing, but in diabetes this frequently occurs at a younger age. Diabetic individuals are more likely to develop age-related comorbidities, such as Alzheimer s disease, cardiovascular disease, osteoporosis, visual impairment and renal dysfunction, indicating that type 2 diabetes itself might represent a pro-ageing state.AIM: To evaluate some phytochemicals for their anti-ageing potential and determine the mechanisms behind this activity.METHODOLOGY: Diabetes and ageing will be induced in Drosophila melanogaster using sucrose and D-galactose respectively. Selected phytochemicals which include gallic acid, tannic acid, quercetin and umbelliferone will then be evaluated for their antidiabetic and anti-ageing potentials. At the end of the experimental period, several parameters will be evaluated using both biochemical and molecular biology techniques.EXPECTED RESULTS: The possible role of the selected phytochemicals in the amelioration of diabetes and ageing will be presented. This will provide the populace with suitable agents for the management of these diseases and their complications

KAZEEM IDOWU is a Associate Professor / Reader at the Department of Biochemistry

KAZEEM has a Ph.D in Biochemistry from University of Ilorin, Ilorin, Nigeria