FAPOHUNDA OLAYINKA DAVID

Physiology

At the Physiology department office

Appointment on Visitation important

Topic: Effects Of Crude Oil Contamination And Microplastics On Male Reproductive System And Sperm Functions

Description: .

#	Certificate	School	Year
1.	M.Sc (Physiology)	Department of Physiology, Lagos State University	2025

Effects of crude oil contamination and microplastics on male reproductive system and sperm functions

Introduction:Exposure to environmental toxicants such as microplastics, and crude oil contamination, prevalent in regions with intensive oil exploration, such as the Niger Delta, poses significant health risks. While much attention has been given to its ecological damage and carcinogenic potential, its impact on reproductive health remains underexplored. Exposure through ingestion, inhalation, or dermal contact introduces toxic compounds that disrupt endocrine functions, impair spermatogenesis and induce oxidative stress, potentially leading to infertility.Hypothesis/Aim/Objectives:I hypothesized that crude oil contaminants and microplastics impair reproduction through endocrine disruption and oxidative stress. Using a wistar rat and porcine models, investigation was carried out on the effects of these toxicants on:1. Gonadotropins FSH, LH , using ELISA.2. Sex-steroid hormones Testosterone, Estradiol , using ELISA.3. Histology of reproductive tissues Testes, Epididymis, Seminal Vesicles, Prostate , using H E Staining technique.4. Sperm parameters Concentration, Motility, Vitality, Kinetics , using Computer-assisted semen analysis.5. Oxidative stress markers, antioxidant enzyme levels, and sperm DNA damage.The therapeutic potential of a plant-derived antioxidant, and supplementation to mitigate possible adverse outcomes will also be investigated.

FAPOHUNDA DAVID is a Graduate Assistant at the Department of Physiology

FAPOHUNDA has a M.Sc in Physiology from Department of Physiology, Lagos State University