Fetal-maternal Medicine And Reproductive Health
Obstetrics and Gynaecology
At the Obstetrics And Gynaecology department office
Appointment on Visitation important
Topic: High Risk Pregnancies And Infertility:endometriosis, Uterine Fibroid And The Menopause
Description: Research into diagnosis and management of high risk pregnancies including hypertensive disorders, diabetes, sickle cell disease and preterm labor. Infertility:endometriosis, uterine fibroid and contraception.
|M.Sc (Human Anatomy)
|Department of Human Anatomy, College of Medicine, University of Lagos
Maternal and Neonatal insulin resistance profile at the Lagos State University Teaching hospital (LASUTH), Ikeja, Lagos.
INTRODUCTION: Studies have documented a significant relationship between maternal insulin resistance and neonatal weight gain in healthy singleton pregnancies. Excessive maternal weight gain in pregnancy and insulin resistance influence fetal growth during normal pregnancy 2. While extremes of birth weights have been documented as risk factors for maternal and neonatal diabetes, maternal contributors to this outcome has not been fully studied. It is therefore important to determine if elevated maternal insulin resistance at term is associated with neonatal outcomes including birth weight appropriate for age.
OBJECTIVES:To determine if elevated maternal insulin resistance, as measured by HOMA-IR at term is associated with neonatal outcomes in healthy pregnancies
METHOD: This is a cross-sectional study being carried out in the clinics and wards of the Department of Obstetrics and Gynaecology, LASUTH. Four hundred women with singleton pregnancies between 37-42 weeks gestational age, are being recruited. Their babies are also recruited within 48 hours of life. Study will last 18 months. Neonates of ill mothers, and those with severe congenital malformations are excluded. Ethical approval was obtained from the Ethics Committee of LASUTH. Written informed consent is obtained from the pregnant women
Fasting venous samples is assayed for plasma glucose and insulin levels. Insulin resistance is determined using the Homeostatic Model Assessment method.
Data will be analysed using statistical package for social sciences (SPSS) version 20. Test for univariate and correlation analysis will be carried out where applicable. Chi-square and ANOVA will be used to compare difference in proportions, and T-test to compare means.
Expected result: This study will identify pregnancies with elevated maternal insulin resistance and associations with neonatal outcomes
Identifying of mothers and infants with insulin resistance may enhance the development of policies and intervention measures directed at preventing the onset of morbidities such as diabetes and cardiovascular disease later in life.
CHIONUMA JOY is a Lecturer I at the Department of Obstetrics and Gynaecology
CHIONUMA has a M.Sc in Human Anatomy from Department of Human Anatomy, College of Medicine, University of Lagos