BANKOLE HABEEB ADEBODUN

Biochemistry

At the Biochemistry department office

Appointment on Visitation important

Topic: Molecular And In Silico Approach To Identify Putative Genes And Pathways Involve In Non-communicable Disease

Description: Introduction: Advancement in molecular biology and the advent of bioinformatics have provided means of identifying and understanding the complex relationship that exist among the most relevant physiological pathways of the onset and progression of most non-communicable diseases. Several genes involved in these diseases have been identified and stored in various databases. These databases can serve as means of curating candidate genes that could serve as biomarkers for screening or/and targets for therapeutics. Screening of biological compounds against these targets would help confirm folkloric claims of the efficacy of such compounds as well as could provide a means of identifying the inhibitory potentials of some active compounds against enzymes in disease conditions.Aim: to identify genes or their protein products that are directly or remotely linked with disease conditions that could be differentially expressed, and could serve as markers for diagnostic or prognosis purposes or targets for targets for therapeutic purposes.Methods: in silico identification of genes and pathways, expression and differential expression of genes will be done using PCR, protein expression analysis will be done using western blot and ELISA analysis, therapeutic potentials of natural products will be confirmed by checking their inhibitory potentials and understanding the mode of inhibition of target enzymes associated with disease conditions

#	Certificate	School	Year
1.	Ph.D (Biotechnology)	University of the Western Cape, Cape Town, South Africa	2016

Anti-aging Potentials of Morinda lucida Leaf in Galactose-Induced Aging in Drosophila Melanogaster Model

Background: Aging is linked with several pathological conditions including oxidative stress, inflammation, hormonal imbalance, and dyslipidemia. Several therapies including diets, herbs, and other natural products have been reported to relieve the process of aging. Morinda lucida is valued for its traditional medical applications. Herbal treatments often incorporate elements of the plant, especially the leaves, roots, and bark. Fruit flies Drosophila melanogaster are a strong model that may be used to examine a variety of biological processes. Its preserved metabolic pathways and genetic tractability make it a perfect model to monitor the effect of natural products as it modulates several human diseases. Aim: This study seeks to evaluate the modulatory effect of M. lucida on some pathological conditions associated with aging. Methodology: D-galactose aging-induced flies were treated with aqueous extract of Morinda lucida leaf for 7 days and 14 days at two different concentrations. Antioxidant enzymes, lipid profiles, inflammatory markers, markers of neurological disorders, and hormones will be monitored in several organs using spectrophotometric methods, commercial biochemical kits, and ELISA kits. Expected results: The result from this research is expected to indicate if the extract of M. lucida has the potential to ameliorate some pathophysiological conditions associated with aging and aging processes.

BANKOLE HABEEB is a Senior Lecturer at the Department of Biochemistry

BANKOLE has a Ph.D in Biotechnology from University of the Western Cape, Cape Town, South Africa