BALOGUN OLADUNNI FATAI

Science Laboratory Technology

At the Science Laboratory Technology department office

Appointment on Visitation important

#	Certificate	School	Year
1.	Ph.D (Botany)	University of the Free State, South Africa	2017

Network pharmacology and molecular docking exploration of probable mechanism of action of Ile-Ife antidiabetic plants in the treatment of Type-2 diabetes mellitus

The prevalence of Type 2 diabetes mellitus (T2DM) continues to grow with increasing population. Available therapeutic options have been characterized with numerous side effects, hence, the clamour for alternative therapeutic option from medicinal plants or natural products becomes a germane option.  The study aimed to unravel novel antidiabetic compounds from Vernonia amygdalina, Musa paradisiaca, Morinda lucida and Carica papaya (VMMC) and determine their mechanism of action with diabetes targeted genes through network pharmacology and preliminary computational method. Compounds from these plants were obtained from scientific literature and Dr. Dukes’ database and screened for pharmacokinetic and ADMET attributes while plant related target and diabetic-related targets were screened using Gene cards and DISGeNet. STRING database and Cytoscape software were used for assessment of protein‒protein interaction networks, while Cytoscape MCODE plugin was used for cluster analysis of the protein modules. Lastly, DAVID database for common targets among compounds targets and T2DM-related targets. A total of 571 compounds were retrieved from the VMMC and upon pharmacokinetic screening gave 333 metabolites used for further analyses. 362 potential therapeutic targets were obtained between VMMC compounds and T2DM. KEGG analysis led to the identification of 26 genes for VMMC from AGE-RAGE pathway and PRKCA, CNR2 and MARK1 were found to be the top genes. Molecular docking results established xysmalogenin, xestoquinone and dehyrocarpaine II as most stable or effective compounds following their binding affinities (-7.9, -6.8 and -6.6 kcal/mol respectively) with respective targets (PRKCA, CNR2 and MARK1 respectively). This study established the preliminary potentials of Ile-Ife medicinal plant compounds as promising candidates in the management of T2DM. Further advance computational tools and experimental studies (in vitro and in vivo) are warranted in order to fully elucidate the MoA and confirm their antidiabetic attributes.

BALOGUN FATAI is a Lecturer II at the Department of Science Laboratory Technology

BALOGUN has a Ph.D in Botany from University of the Free State, South Africa