Meet ANJORIN ABDULAZEEZ ADEYEMI, an Academic Staff of Lagos State University.
Virology
Senior Lecturer
Microbiology
At the Microbiology department office
Appointment on Visitation important
Topic: Medical And Molecular Virology Research
Description: My research interest is in the field of Medical Microbiology working on microbial pathogens with specialization in virology especially viruses of public health importance for epidemiological surveillance cutting across One-health. The research focus is on detection and characterization of influenza and other respiratory viruses using serological and molecular techniques for possible drug design/vaccine production. Also, isolation of viruses for antiviral studies and vaccine adverse events studies.
| # | Certificate | School | Year |
|---|---|---|---|
| 1. | Ph.D (Medical Microbiology Virology ) | University of Lagos | 2020 |
Translating Genomic Surveillance Data into Effective Lassa Diagnostic Tools
Introduction
Conducting genomic surveillance on Lassa virus will help to gain insights into the genetic diversity of the virus and potentially identify new strains or mutations that may influence the virus's transmission, virulence, or response to treatment.
Aim
To carryout genomic surveillance of Lassa virus and investigate the prevalence in rodent population for diagnostics in Nigeria.
Objectives
1. To screen for LASV exposure among the febrile patients.
2. To conduct comprehensive genomic surveillance of Lassa virus strains circulating among febrile patients.
3. To investigate the prevalence of Lassa virus in rodent populations to understand the potential reservoirs.
4. To do molecular characterization and comparison of the phylogenetic relatedness among the strains of LASV detected in human samples with the strains detected in animal samples.
5. To identify and validate robust antigenic targets for LASV diagnostics.
Methodology
1. Antibody detection will be done using ELISA.
2. RT-PCR for LASV will be done to detect the presence of
S-gene of LASV RNA, followed by Next-generation sequencing for genetic variations.
3. Phylogenetic analysis to understand the evolutionary relationships and potential sources of Lassa virus will be carried out.
4. Target identification, Antigen expression and Antigen optimization will be done using Bioinformatics tools to compare LASV strains and select conserved regions for antigen design will be executed.
Expected results and Contributions to knowledge
At the end of this study, the Molecular epidemiology of Lassa virus among humans and rodents would be better known. The virus strains driving the epidemic and mutation pattern will be clarified and the strain sequences will be deposited in the Gene Bank. This study is significant as it may provide insights into the causes of persistent outbreaks of Lassa fever. It could lead to the development of novel diagnostic tools with improved sensitivity and specificity compared to existing methods.ANJORIN ABDULAZEEZ is a Senior Lecturer at the Department of Microbiology
ANJORIN has a Ph.D in Medical Microbiology Virology from University of Lagos
