AMOLE OLATOKUNBOH OLUFEMI

Pharmacology, Therapeutics & Toxicology

At the Pharmacology, Therapeutics & Toxicology department office

Appointment on Visitation important

Topic: Chemotherapy/Toxicology

Description: My orientation of research is towards chemotherapy, which is the use of drugs medicinal plants in the treatment of diseases, and toxicity studies, to know whether these medicinal plants are toxic or safe for human consumption. Another area of myresearch is Medical Education. There is the use of medicinal plants in the treatment of diseases like Diabetes,malaria,aging convulsion inflammation, HIV/AIDS etc. Claims were been made by Nigerian Traditional Medicinal Practitioners who use these medicinal plants on their patients. These proclamations prompted the ongoing ongoing investigation of screening for efficacy of some medicinal plants in treatment of diseases. We also think that some of these medicinal plants may even solve the problems of resistance and side effects being encountered with many drugs.Presently, the research is directed towards knowing the mechanisms of actions of these plant drugs in the treatment of diseases

#	Certificate	School	Year
1.	Ph.D (Pharmacology)	Department of Pharmacology University of Lagos College of Medicine , Idi-Araba Lagos	1999

Effects of Riboceine Cellgevity on Ulcer Models in Rats

Ulcer has been associated with acid secretion in the mucosa. Recent studies have shown that prostaglandins inhibit gastric secretion, stimulates bicarbonate secretion and increases gastric blood volume, and important in the pathophysiology of peptic ulcer disease and possibly in its prevention and treatment. Studies have shown that glutathione promotes biosynthesis of leukotrienes and prostaglandins. Riboceine is a glutathione precursor. The study was conducted to determine the effect of riboceine on ulcer models in rats. Riboceine was administered at 7mg/kg, 14mg/kg, and 28mg/kg for seven days orally. Misoprostol 50ug/kg was used a positive control orally. The prophylactic activity was investigated using ethanol, diclofenac and pylorus-ligation-induced gastric ulcer models in rats. In the ethanol-induced gastric ulcer model, there was a significant reduction p&0.05 in the ulcer index by riboceine 28mg/kg which produced 60% protection and lowest number of lesions. In diclofenac-induced gastric ulcer model, there was no significant reduction in the ulcer index by riboceine at all doses. Riboceine 14mg/kg produced 72.72% protection and lowest number of lesion. In pylorus ligation-induced gastric ulcer model, there was a significant reduction p&0.01, p&0.01, p&0.01 in the ulcer index by riboceine 7mg/kg, 14mg/kg, 28mg/kg respectively. Riboceine 7 mg/kg produced 87.36% protection and lowest number of lesions which was lesser than that of misoprostol 50mg/kg , which produced 96.84% protection. Riboceine also showed no significant difference in the volume of gastric secretion and no significant differences in the effect of pH when compared with control. Overall, this study showed that riboceine is effective as a preventive measure in ulcer. A possible mechanism of action is by mucosal protection.

AMOLE OLUFEMI is a Professor at the Department of Pharmacology, Therapeutics & Toxicology

AMOLE has a Ph.D in Pharmacology from Department of Pharmacology University of Lagos College of Medicine , Idi-Araba Lagos