Meet ALLEN MICHAEL OLABODE, an Academic Staff of Lagos State University.
Smooth Muscle
Assistant Lecturer
Physiology
At the Physiology department office
Appointment on Visitation important
| # | Certificate | School | Year |
|---|---|---|---|
| 1. | M.Sc (Physiology) | Department of Physiology, University of Ilorin | 2017 |
Investigation into aortic smooth muscle activities of Terminalia glaucescens on male Wistar rats
Smooth muscle encircles the hollow organs of the body and functions to regulate and/or mediate the flow of fluids by changing the diameter of the organ through contractions and relaxation. Smooth muscle plays an important role in the disease process throughout the body and has been implicated in many clinically important pathologies mostly related to the contractile state of the smooth muscle such as asthma, hypertension, septic shock, migraine, motility disorders, erectile dysfunction etc. Natural products like plants have contributed significantly to the discovery of new drugs. The plant T. glaucescens has been reported to contain arjunic acid which is also found in Terminalia arjuna that has been strongly researched for its cardiovascular and inotropic effects. The genus T. glaucescens has basically been reported for its antimicrobial activities and anti-inflammatory properties which support the local use in Nigeria as a chewing stick. The plant shares similar medicinal properties such as anti-atherogenic, hypolipidemic actions, hepatoprotection, antioxidant, and antimicrobials with other species of the genus Terminalia. With no studies on its smooth muscle activities, the research is therefore carried out to provide such information and its possible mechanisms of action. The studies involve both in-vitro and in-vivo studies on laboratory rats that uses normotensive and hypertensive rats to determine the roles of different channels and intracellular enzymes in smooth muscle activities of T. glaucescens. This is done using a force transducer model 7004; UgoBasile Varese, Italy connected to Data capsule acquisition system model 17400 to determine this. The study is expected to uncover the possible endothelium and non-endothelium involvement in the smooth muscle response to the extracts, the role of various receptors and channels along with the enzymes involve in smooth muscle calcium sensitization and inhibition. The findings from this study can be of pharmacological importance to the discovery of new drugs.
ALLEN MICHAEL is a Assistant Lecturer at the Department of Physiology
ALLEN has a M.Sc in Physiology from Department of Physiology, University of Ilorin
