AJONUMA LOUIS CHUKWUEMEKA

Physiology

At the Physiology department office

Appointment on Visitation important

Topic: Reproductive Physiology & Endocrinology

Description: Interaction of reproductive tract epithelia and gametes, spermatogenesis & sperm maturation, ovulation, fertilization

#	Certificate	School	Year
1.	Ph.D (Reproductive Physiology/Physiology)	Department of Physiology, The Chinese University of Hong Kong	2004

The role of CFTR gene in cabergoline amelioration of ovarian hyperstimulation syndrome using a rat model.

Introduction: It has been demonstrated recently that suppression of CFTR by progesterone inhibits transepithelial transport of fluids during OHSS treatment with progesterone. Objectives: However, the mechanism of action by cabergoline has not been elicited. It is not known if carbagoline also suppress CFTR expression. Methods: Twenty female Sprague Dawley SD rats will be divided into 4 groups of 5 rats. Group A was the control no treatment, while groups B, C and D served as the test groups. Group A received 0.5ml of normal saline daily while groups B, C and D superovulated to induce OHSS. B receive also orally 0.5ml of normal saline daily while C and D progesterone 25mg/kg and D cabergoline for 4 days. Body weights obtained. Serum samples obtained from the rats will be assayed for reproductive hormones Follicle Stimulating Hormone FSH , Luteinizing Hormone LH and Estradiol E2 . Uterus for histology. We will use real-time reverse transcriptase chain reaction RT-PCR methods. Western blot analysis, immunofluorescence and light microscopy will also be used. Contribution to knowledge: The findings, will demonstrate CFTR involvement during OHSS treatment using cabergoline.

AJONUMA LOUIS is a Professor at the Department of Physiology

AJONUMA has a Ph.D in Reproductive Physiology/Physiology from Department of Physiology, The Chinese University of Hong Kong