Reproductive Endocrinology And Infertility
Obstetrics and Gynaecology
At the Obstetrics And Gynaecology department office
Appointment on Visitation important
Topic: Antimullerian Hormone Levels In Women With Sickle Cell Disease In Lagos State University Teaching Hospital, Ikeja-Lagos.
Description: Sickle cell disease is the commonest inherited condition world-wide with the highest incidence among the black race. It is characterized by chronic hypoxia with damage to vital organs including the ovaries. The study sets out to assess the ovarian reserve of women in the reproductive age group with sickle cell disease so as to use the information in counseling them with respect to their reproductive potential. This is a case-contolled study involving women with sickle cell disease and women with normal haemoglobin genotype who fulfill the inclusion criteria. A proforma will be used to collect data from participants and blood will be taken and assayed for antimulllerian hormone. Results will be analyzed using SPSS-a statistical soft ware.
|1.||M.B.B.S- Unclassified Degree in Medicine and Surgery ()||College Of Medicine, University Of Lagos||1986|
Use Of Sublingual Misoprostol And Oxytocin Versus Oxytocin Alone In The Prevention Of Primary Post-Partum Haemorrhage: A Randomized Control Trial At Lagos State University Teaching Hospital.
This study compared the efficacy and untowards effects developed following administration of sublingual misoprostol plus intramuscular oxytocin with that due to intramuscular oxytocin alone in active management of third stage of labour.
This double blind, placebo-controlled randomized study was carried out at the maternity units of the Department of Obstetrics and Gynaecology, Lagos State University Teaching Hospital situated at Maternal and Child Centres, Ifako-Ijaye and Isolo. Of a target sample size of 1050, 1036(98.7%) eligible parturients were randomly allocated to receive either 400µg of sublingual misoprostol (519 participants) or 2 tablets of placebo (517 participants), in addition to standard active management of the third stage of labour, immediately after vaginal delivery. Blood samples were collected for pre-delivery and post-partum haemoglobin concentration and the difference calculated. The mean blood loss, incidence of postpartum haemorrhage and presence of untowards effects were evaluated. Data obtained was collated and analysed.
The frequency of participants with blood loss of 500ml or more within 1 hour of administration of trial drugs was not statistically significant in the 2 arms (misoprostol 5.4% versus placebo 7.5%) with relative risk, 0.72; 95% confidence interval, 0.45 - 1.14. There was statistically significant difference in the mean blood loss (misoprostol 229.73 + 108.12ml versus placebo 274.58 + 121.09ml) with p-value < 0.001. Additional uterotonics was less significantly required while shivering and pyrexia was more significantly observed in the misoprostol arm relative to the placebo arm.
The study demonstrated that 400 micrograms of sublingual misoprostol plus 10 iu of oxytocin compared with oxytocin alone as a component of active management of third stage of labour although confers no significant advantage in the reduction of the risk of primary postpartum haemorrhage,but has shown some promise evidenced by reduction in the mean blood loss and requirement for additional uterotonics.
ADEWUNMI ADENIYI is a Professor at the Department of Obstetrics and Gynaecology
ADEWUNMI has a M.B.B.S- Unclassified Degree in Medicine and Surgery in from College Of Medicine, University Of Lagos