Meet ADEKUNBI TOBI STEPHEN, an Academic Staff of Lagos State University.
Biochemical Toxicology And Drug Discovery
Assistant Lecturer
Medical Biochemistry
At the Medical Biochemistry department office
Appointment on Visitation important
Topic: Biochemical Toxicology And Drug Discovery
Description: This involves the use of novel plant extracts that can circumvent different side effects produced by synthetic drugs used for the treatment of Non-alcoholic fatty liver disease and related diseases
| # | Certificate | School | Year |
|---|---|---|---|
| 1. | M.Sc (BIOCHEMISTRY) | COVENANT UNIVERSITY | 2019 |
Evaluation of the preventive and curative roles of Olax Subscorpioidea in diet-induced non-alcoholic fatty liver diseased male Wistar rats
Specific Objectives of Research: a . Conduct preliminary qualitative and quantitative phytochemical analyses of the aqueous, ethanolic and 50% hydroethanolic extracts of aerial parts of Senna alata Asuwon Oyinbo , Olax subscorpioidea Ifon , and rhizome of Curculigo pilosa Epakun ; b . Determine the in vitro antioxidants profile of the aqueous, ethanolic and 50% hydroethanolic extracts of the plants; c . Determine the secondary metabolites/phytoconstituents in the aqueous, ethanolic and 50% hydroethanolic extracts of the plants using gas chromatography-coupled mass spectrometry GC-MS and other spectral studies; d . Evaluate the safety profile of the aqueous, ethanolic and 50% hydroethanolic extracts of the plants in animal models using the OECD acute oral toxicity studies and repeat dose sub chronic oral toxicity studies; e . Based on the outcome of objectives a - d determine the most effective of the nine extracts investigated and determine three effective graded oral doses of this extract; f . Evaluate ameliorative potential of the three graded oral doses of the extract in both the preventive and curative models of diet-induced non-alcoholic fatty liver disease NAFLD male Wistar rats using standard procedures; Expected Contribution to Knowledge a . The study will identify the secondary metabolites and their relative abundance in aqueous, ethanolic and 50% hydroethanolic extracts of aerial parts of Senna alata Asuwon Oyinbo , Olax subscorpioidea Ifon , and rhizome of Curculigo pilosa Epakun ; b . The study will determine the most effective of the aqueous, ethanolic and 50% hydroethanolic extracts of Senna alata Asuwon Oyinbo , Olax subscorpioidea Ifon , and rhizome of Curculigo pilosa Epakun ; in ameliorating and preventing diet-induced non alcoholic fatty liver diseased male Wistar rats; c . The study will confirm or disapprove the ameliorative or curative activity of the selected plant extracts against NAFLD d . The study is expected to discover pro-drugs for scientists in drug discovery and development
ADEKUNBI TOBI is a Assistant Lecturer at the Department of Medical Biochemistry
ADEKUNBI has a M.Sc in BIOCHEMISTRY from COVENANT UNIVERSITY
