Oral & Maxillofacial Pathology
Oral Pathology / Oral Medicine
At the Oral Pathology / Oral Medicine department office
Appointment on Visitation important
Topic: Odontogenic Tumours, Head And Neck Carcinomas And Infections
The focus of my research and contribution to knowledge in the field of Oral and Maxillofacial pathology has been in:
Head and Neck carcinomas
Odontogenic tumours: This group of neoplasms which is relatively common in our environment has been reported to be more common in the black African population than in other racial groups. This area has been the major thrust of my research activity (papers 2, 3, 5 and 11). Our study on Ectodermal odontogenic tumours (paper 3) and on histological variants of ameloblastoma (paper 11), was carried out to establish the relative incidence and provide clinico-pathologic information on the various histologic types seen in our environment in order to provide a baseline data which will be of significance to the pathologist and clinician. It was observed that central ameloblastoma was the commonest ectodermal odontogenic tumour accounting for 88.3% of the cases analysed.
Histochemical staining using silver nitrate to demonstrate AgNOR(Argyrophylic Nucleolar Organizer Region) dots in cells was used to analyse the biologic behaviour of benign and malignant ectodermal odontogenic tumours (paper 5) as estimation of AgNOR dots reflects replicatory activities within nuclei of cells. The usefulness of AgNORS as a quantitative criteria in assessing the biologic behaviour of these tumours was clearly established in our study as we showed that AgNOR quantification correlates with clinical behavior and that clear cell differentiation potentiates biologic aggression of ectodermal odontogenic tumours. Our study showed a clear trend for higher AgNOR counts in malignant ectodermal odontogenic tumours and those with clear cell differentiation than their benign counterparts. We established that AgNOR is a quantitative discriminatory aid easy to monitor in a pathology laboratory in detecting incipient cellular alterations. Perhaps future studies may be able to ascertain whether it would be useful in determining which lesions have a greater potential for recurrence.
Ameloblastic carcinoma is an exceptionally rare and aggressive orofacial neoplasm that belong to the family of ectodermal odontogenic tumours. We reported 3 cases( paper 2) which had 2 recurrences and 1 death. We also reported a case of clear cell odontogenic carcinoma (paper 8) which is a rare odontogenic tumour, occurring in the maxilla of a 45year old female Nigerian and showing evidence of regional cervical lymph node matastasis.We therefore emphasized that cases of ameloblastoma be treated with radical surgery to prevent recurrence or malignant transformation especially in sub-saharan Africa where patients are unable to bear the financial burden of multiple surgery and radiotherapy
Head and Neck carcinomas: Our study on orofacial squamous cell carcinoma (paper 4) showed that they constitute 78.7% of all orofacial malignancies and that the maxillary antrum was the commonest site (20.3%). Our report substantiates the results of other studies that late presentation of orofacial diseases is a common phenomenon in most developing countries. We suggested that since majority of these lesions were well differentiated, there is need for intensive oral health awareness to encourage early presentation as this will further enhance prognosis. The prevalence of orofacial squamous cell carcinoma show the need for the establishment of a virile oncology policy with active collaboration of voluntary agencies and availability of the required chemotherapeutic agents and hospital care at affordable costs.
Infections: In collaboration with other workers we explored the problem of salivary gland enlargement as a complication of HIV infection (paper 7). We established that parotid gland enlargement may be the presenting clinical manifestation of HIV/AIDS in the African as in other races. Histological report from our reported cases showed massive lymphoepithelial infiltration and eosinophylic deposits believed to be amyloid. We also showed that the use of imaging techniques and fine needle aspiration (FNA) biopsy in collaboration with histological analysis may help increase the accuracy of diagnosis and differentiation of the lesion from other parotid lesion like marginal zone B-cell lymphomas.
|1.||FICD (Dentistry)||International College of Dentists||2018|
Review of cases of squamous cell carcinoma of the jaws in LaLagos State University Teaching Hospital
Squamous cell carcinoma is the commonest malignant lesion seen in the orofacial region in our environment. This is a review of cases seen in Lagos State University Teaching Hospital
ADEBIYI KEHINDE is a Professor at the Department of Oral Pathology / Oral Medicine
ADEBIYI has a FICD in Dentistry from International College of Dentists