ABIDOYE OLADELE ADEBAYO

Physiology

At the Physiology department office

Appointment on Visitation important

Topic: Atrial Natriuretic Peptide Levels On Salt Loading In Healthy Nigerians With Variations In Body Mass Index

Description: Weight gain is invariably associated with increased blood pressure and diabetes mellitus. The basis is not fully known, atrial natriuretic peptide might play a role. The research aims to investigate atrial natriuretic peptide levels in healthy normotensive Nigerians with variations in body mass index. Atria natriuretic peptide is a cardiac hormone, released into the circulation in response to myocardial stretch, resulting from increased blood volume. The hormone promotes natriuresis, diuresis and vasodilation in order to reduce blood pressure. Although, the role of atrial natriuretic peptide hormone in blood pressure control is receiving much attention among cardiovascular researchers, there is paucity of data regarding its role in obesity and diabetes in Africa, most especially in a Nigerian population. It has been suggested that atrial natriuretic peptide influences glucose metabolism. Once associated only with high income countries, overweight and obesity are also prevalent in low and middle income nations of the world. It is documented that in Urban West Africa, the rates of obesity have more than double in the last 15 years and are three times more common in females than males. Although, ones lifestyle plays a role in weight gain, the study will attempt to shed more light on the possible role of atrial natriuretic peptide hormone in obesity in a Nigerian population.

#	Certificate	School	Year
1.	Ph.D (Physiology)	Physiology. University of Lagos	2020

Vitamin B6 and 12 Supplementation Promotes Vascular Normoreactivity but Suppresses Hyperreactivity in Healthy Normotensive Nigerians

Vascular hyperreactivity has been linked with the development of hypertension. The role of Vitamins B6 and 12 on vascular reactivity in a black population has not been investigated.Objective: To assess effects of Vitamin B6 and 12 supplementations on vascular reactivity in healthy normotensive NigeriansMethods: Forty-eight apparently healthy normotensive Nigerians were instructed to immerse one foot into ice slurry maintained at 4 C for 1 min. Their systolic blood pressure SBP , diastolic blood pressure DBP and Mean arterial blood pressure MABP were determined before exposure to cold pressor test CPT , in order to determined their vascular reactivity. Vitamins B6 and 12 were then administered for 6 weeks in the participants and their vascular reactivity was reassessed. Vascular hyperreactivity to CPT was determined by a change in SBP or DBP 15mmHg while a normoreactivity was less.Results: CPT significantly raised SBP, DBP and MABP but following vitamin B supplementation, the elevated SBP in the volunteers fell with no significant increase in MABP. Although, most participants demonstrated normoreactivity to CPT in their SBP and DBP 75% and 90%, respectively ; no fewer than 25% of them exhibited hyperreactivity in SBP while 10% in DBP. However, upon vitamin B administration, the percentages of both systolic and diastolic normoreactivity rose to 96% while that of systolic and diastolic hyperreactivity decreased to 4%. Conclusion: These findings imply that although CPT induces blood pressure increase, Vitamin B6 and 12 supplementation promotes vascular normorreactivity but suppresses hyperreactivity in healthy normotensive Nigerians.

ABIDOYE OLADELE is a Senior Lecturer at the Department of Physiology

ABIDOYE has a Ph.D in Physiology from Physiology. University of Lagos