ABIDOYE OLADELE ADEBAYO

Physiology

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Topic: Atrial Natriuretic Peptide Levels On Salt Loading In Healthy Nigerians With Variations In Body Mass Index

Description:

Weight gain is invariably associated with increased blood pressure and diabetes mellitus. The basis is not fully known, atrial natriuretic peptide might play a role. The research aims to investigate atrial natriuretic peptide levels in healthy normotensive Nigerians with variations in body mass index.  Atria natriuretic peptide is a cardiac hormone, released into the circulation in response to myocardial stretch, resulting from increased blood volume. The hormone promotes natriuresis, diuresis and vasodilation in order to reduce blood pressure. Although, the role of atrial natriuretic peptide hormone in blood pressure control is receiving much attention among cardiovascular researchers, there is paucity of data regarding its role in obesity and diabetes in Africa, most especially in a Nigerian population. It has been suggested that atrial natriuretic peptide influences glucose metabolism. Once associated only with high income countries, overweight and obesity are also prevalent in low and middle income nations of the world. It is documented that in Urban West Africa, the rates of obesity have more than double in the last 15 years and are three times more common in females than males. Although, one's lifestyle plays a role in weight gain, the study will attempt to shed more light on the possible role of atrial natriuretic peptide hormone in obesity in a Nigerian population.

#	Certificate	School	Year
1.	Ph.D (Physiology)	Physiology. University of Lagos	2020

Atrial Natriuretic Peptide Levels on Salt Loading in Healthy Adult Nigerians with Variations in Body Mass Index

Weight gain is invariably associated with increased blood pressure and diabetes mellitus. The basis is not fully understood, atrial natriuretic peptide hormone might play a role in the pathogenesis. Aim is to assess and compare plasma atrial natriuretic peptide levels on salt loading in healthy adult Nigerians. Apparently healthy normotensive, not diabetic Nigerians were recruited for the study after they had been properly informed about the study and informed consent was obtained. Ethical approval was also obtained from Health Research Committee of the Colege of Medicine of the University of Lagos, Idi-Araba, Lagos. Inclusion and exclusion criteria were dully observed in selection of the volunteers. Anthropometric data of the participants such as age, body weight, height and body ass index were determined. Age was recorded in years, body weight was measured using a weighing scale, height was measured using stadiometer while body mass index was calculated by dividing the body weight in kilogrammes by the square of height in metres. Plasma atrial natriuretic peptide levels and cardiovascular parameters such as heart rate, systolic and diastolic blood pressures were measured before and after salt loading. Heart rate was determined electrocardiograph machine while blood pressure was measured by auscultatory measure using Accoson mercury sphygmomanometer. Having determined the baseline laboratory and cardiovascular parameters, the participants were administered 200 mmol of sodium in two divided doses per day for 5 days. The parameters were measured again on the 6th day after 5-day period of salt loading. Data was analyzed using Graphpad Statistical Software, Version 5 for windows. Student t test and ANOVA were employed where appropriate. Results, discussion and conclusion are yet to be concluded

ABIDOYE OLADELE is a Lecturer I at the Department of Physiology

ABIDOYE has a Ph.D in Physiology from Physiology. University of Lagos